BACKGROUND: Lymphedema (LE) is a frequent complication following breast cancer treatment. While progress is being made in the identification of phenotypic risk factors for the development of LE, little information is available on the molecular characterization of LE. The purpose of this study was to determine if variations in pro- and anti-inflammatory cytokine genes were associated with LE following breast cancer treatment. METHODS AND RESULTS: Breast cancer patients completed a number of self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping was done using a custom genotyping array. No differences were found between patients with (n=155) and without LE (n=387) for the majority of the demographic and clinical characteristics. Patients with LE had a significantly higher body mass index, more advanced disease, and a higher number of lymph nodes removed. Genetic associations were identified for three genes (i.e., interleukin (IL4) 4 (rs2227284), IL 10 (rs1518111), and nuclear kappa factor beta 2 (NFKB2 (rs1056890)) associated with inflammatory responses. CONCLUSIONS: These genetic associations suggest a role for a number of pro- and anti-inflammatory genes in the development of LE following breast cancer treatment.
BACKGROUND:Lymphedema (LE) is a frequent complication following breast cancer treatment. While progress is being made in the identification of phenotypic risk factors for the development of LE, little information is available on the molecular characterization of LE. The purpose of this study was to determine if variations in pro- and anti-inflammatory cytokine genes were associated with LE following breast cancer treatment. METHODS AND RESULTS:Breast cancerpatients completed a number of self-report questionnaires. LE was evaluated using bioimpedance spectroscopy. Genotyping was done using a custom genotyping array. No differences were found between patients with (n=155) and without LE (n=387) for the majority of the demographic and clinical characteristics. Patients with LE had a significantly higher body mass index, more advanced disease, and a higher number of lymph nodes removed. Genetic associations were identified for three genes (i.e., interleukin (IL4) 4 (rs2227284), IL 10 (rs1518111), and nuclear kappa factor beta 2 (NFKB2 (rs1056890)) associated with inflammatory responses. CONCLUSIONS: These genetic associations suggest a role for a number of pro- and anti-inflammatory genes in the development of LE following breast cancer treatment.
Authors: Christina Van Onselen; Bruce A Cooper; Kathryn Lee; Laura Dunn; Bradley E Aouizerat; Claudia West; Marylin Dodd; Steven Paul; Christine Miaskowski Journal: Support Care Cancer Date: 2012-10 Impact factor: 3.603
Authors: Don Vu; Eglis Tellez-Corrales; Prashant Sakharkar; Michael Scott Kissen; Tariq Shah; Ian Hutchinson; David I Min Journal: Transpl Immunol Date: 2012-11-12 Impact factor: 1.708
Authors: Christine Miaskowski; Bruce Cooper; Steven M Paul; Claudia West; Dale Langford; Jon D Levine; Gary Abrams; Deborah Hamolsky; Laura Dunn; Marylin Dodd; John Neuhaus; Christina Baggott; Anand Dhruva; Brian Schmidt; Janine Cataldo; John Merriman; Bradley E Aouizerat Journal: J Pain Date: 2012-12 Impact factor: 5.820
Authors: Shin Lin; Jeanna Kim; Mi-Joung Lee; Leslie Roche; Nancy L Yang; Philip S Tsao; Stanley G Rockson Journal: PLoS One Date: 2012-12-18 Impact factor: 3.240
Authors: Eeeseung Byun; Caryl L Gay; Carmen J Portillo; Clive R Pullinger; Bradley E Aouizerat; Kathryn A Lee Journal: Sleep Med Date: 2017-01-20 Impact factor: 3.492
Authors: Betty Smoot; Kord M Kober; Steven M Paul; Jon D Levine; Gary Abrams; Judy Mastick; Kimberly Topp; Yvette P Conley; Christine A Miaskowski Journal: Nurs Res Date: 2017 Mar/Apr Impact factor: 2.381
Authors: Christine Miaskowski; Yvette P Conley; Judy Mastick; Steven M Paul; Bruce A Cooper; Jon D Levine; Mitchell Knisely; Kord M Kober Journal: J Pain Symptom Manage Date: 2017-08-08 Impact factor: 3.612
Authors: Olga V Saik; Vadim V Nimaev; Dilovarkhuja B Usmonov; Pavel S Demenkov; Timofey V Ivanisenko; Inna N Lavrik; Vladimir A Ivanisenko Journal: BMC Med Genomics Date: 2019-03-13 Impact factor: 3.063
Authors: Simona F Shaitelman; Kate D Cromwell; John C Rasmussen; Nicole L Stout; Jane M Armer; Bonnie B Lasinski; Janice N Cormier Journal: CA Cancer J Clin Date: 2014-11-19 Impact factor: 508.702
Authors: Mei R Fu; Yvette P Conley; Deborah Axelrod; Amber A Guth; Gary Yu; Jason Fletcher; David Zagzag Journal: Breast Date: 2016-07-22 Impact factor: 4.380
Authors: Michael Bernas; Saskia R J Thiadens; Betty Smoot; Jane M Armer; Paula Stewart; Jay Granzow Journal: Clin Exp Metastasis Date: 2018-05-17 Impact factor: 5.150