D Chernyak1, V Gevorgyan1. 1. University of Illinois at Chicago, 845 West Taylor St., Chicago 60607, Illinois, USA.
Abstract
Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this cascade transformation, which proceeds through an SN2'-substitution followed by a consequent cycloisomerization step.
Organocuprates efficiently undergo reaction with heterocyclic n class="Chemical">propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this cascade transformation, which proceeds through an SN2'-substitution followed by a consequent cycloisomerization step.
Authors: Alexander S Dudnik; Anna W Sromek; Marina Rubina; Joseph T Kim; Alexander V Kel'in; Vladimir Gevorgyan Journal: J Am Chem Soc Date: 2008-01-04 Impact factor: 15.419
Authors: Todd Schwier; Anna W Sromek; Dahrika M L Yap; Dmitri Chernyak; Vladimir Gevorgyan Journal: J Am Chem Soc Date: 2007-07-21 Impact factor: 15.419