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Literature DB >> 24501305

MYCxing it up with FGFR1 in squamous cell lung cancer.

Abstract

Recurrent amplification of 8p12 is observed in squamous cell lung cancer, and FGFR1 is thought to be the main oncogenic driver in this region. In this issue of Cancer Discovery, Malchers and colleagues perform a detailed characterization of 8p12 in squamous cell lung cancer and find remarkable genomic heterogeneity in this region, raising the possibility that other genes in addition to FGFR1 may play a role in squamous cell lung cancer. Mechanistic studies of the FGFR1-amplified subset of squamous cell lung cancer reveal potential roles for fibroblast growth factor (FGF) ligands and MYC expression levels in modulating the response of these tumors to FGF receptor inhibition. 2014 AACR

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 24501305 PMCID： PMC4074909 DOI： 10.1158/2159-8290.CD-13-1049

Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397

12 in total

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Authors: Timothy R Wilson; Jane Fridlyand; Yibing Yan; Elicia Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Yulei Wang; Jeff Sosman; Antoni Ribas; Jiang Li; John Moffat; Daniel P Sutherlin; Hartmut Koeppen; Mark Merchant; Richard Neve; Jeff Settleman
Journal: Nature Date: 2012-07-26 Impact factor: 49.962

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Authors: Giovanni Tonon; Kwok-Kin Wong; Gautam Maulik; Cameron Brennan; Bin Feng; Yunyu Zhang; Deepak B Khatry; Alexei Protopopov; Mingjian James You; Andrew J Aguirre; Eric S Martin; Zhaohui Yang; Hongbin Ji; Lynda Chin; Ronald A Depinho
Journal: Proc Natl Acad Sci U S A Date: 2005-06-27 Impact factor: 11.205

3. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.

Authors: Peter S Hammerman; Martin L Sos; Alex H Ramos; Chunxiao Xu; Amit Dutt; Wenjun Zhou; Lear E Brace; Brittany A Woods; Wenchu Lin; Jianming Zhang; Xianming Deng; Sang Min Lim; Stefanie Heynck; Martin Peifer; Jeffrey R Simard; Michael S Lawrence; Robert C Onofrio; Helga B Salvesen; Danila Seidel; Thomas Zander; Johannes M Heuckmann; Alex Soltermann; Holger Moch; Mirjam Koker; Frauke Leenders; Franziska Gabler; Silvia Querings; Sascha Ansén; Elisabeth Brambilla; Christian Brambilla; Philippe Lorimier; Odd Terje Brustugun; Aslaug Helland; Iver Petersen; Joachim H Clement; Harry Groen; Wim Timens; Hannie Sietsma; Erich Stoelben; Jürgen Wolf; David G Beer; Ming Sound Tsao; Megan Hanna; Charles Hatton; Michael J Eck; Pasi A Janne; Bruce E Johnson; Wendy Winckler; Heidi Greulich; Adam J Bass; Jeonghee Cho; Daniel Rauh; Nathanael S Gray; Kwok-Kin Wong; Eric B Haura; Roman K Thomas; Matthew Meyerson
Journal: Cancer Discov Date: 2011-06 Impact factor: 39.397

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Journal: Nature Date: 2007-11-04 Impact factor: 49.962

5. Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinoma.

Authors: William W Lockwood; Raj Chari; Bradley P Coe; Kelsie L Thu; Cathie Garnis; Chad A Malloff; Jennifer Campbell; Ariane C Williams; Dorothy Hwang; Chang-Qi Zhu; Timon P H Buys; John Yee; John C English; Calum Macaulay; Ming-Sound Tsao; Adi F Gazdar; John D Minna; Stephen Lam; Wan L Lam
Journal: PLoS Med Date: 2010-07-27 Impact factor: 11.069

6. Somatic mutations affect key pathways in lung adenocarcinoma.

Authors: Li Ding; Gad Getz; David A Wheeler; Elaine R Mardis; Michael D McLellan; Kristian Cibulskis; Carrie Sougnez; Heidi Greulich; Donna M Muzny; Margaret B Morgan; Lucinda Fulton; Robert S Fulton; Qunyuan Zhang; Michael C Wendl; Michael S Lawrence; David E Larson; Ken Chen; David J Dooling; Aniko Sabo; Alicia C Hawes; Hua Shen; Shalini N Jhangiani; Lora R Lewis; Otis Hall; Yiming Zhu; Tittu Mathew; Yanru Ren; Jiqiang Yao; Steven E Scherer; Kerstin Clerc; Ginger A Metcalf; Brian Ng; Aleksandar Milosavljevic; Manuel L Gonzalez-Garay; John R Osborne; Rick Meyer; Xiaoqi Shi; Yuzhu Tang; Daniel C Koboldt; Ling Lin; Rachel Abbott; Tracie L Miner; Craig Pohl; Ginger Fewell; Carrie Haipek; Heather Schmidt; Brian H Dunford-Shore; Aldi Kraja; Seth D Crosby; Christopher S Sawyer; Tammi Vickery; Sacha Sander; Jody Robinson; Wendy Winckler; Jennifer Baldwin; Lucian R Chirieac; Amit Dutt; Tim Fennell; Megan Hanna; Bruce E Johnson; Robert C Onofrio; Roman K Thomas; Giovanni Tonon; Barbara A Weir; Xiaojun Zhao; Liuda Ziaugra; Michael C Zody; Thomas Giordano; Mark B Orringer; Jack A Roth; Margaret R Spitz; Ignacio I Wistuba; Bradley Ozenberger; Peter J Good; Andrew C Chang; David G Beer; Mark A Watson; Marc Ladanyi; Stephen Broderick; Akihiko Yoshizawa; William D Travis; William Pao; Michael A Province; George M Weinstock; Harold E Varmus; Stacey B Gabriel; Eric S Lander; Richard A Gibbs; Matthew Meyerson; Richard K Wilson
Journal: Nature Date: 2008-10-23 Impact factor: 49.962

7. Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer.

Authors: Florian Malchers; Felix Dietlein; Jakob Schöttle; Xin Lu; Lucia Nogova; Kerstin Albus; Lynnette Fernandez-Cuesta; Johannes M Heuckmann; Oliver Gautschi; Joachim Diebold; Dennis Plenker; Masyar Gardizi; Matthias Scheffler; Marc Bos; Danila Seidel; Frauke Leenders; André Richters; Martin Peifer; Alexandra Florin; Prathama S Mainkar; Nagaraju Karre; Srivari Chandrasekhar; Julie George; Steffi Silling; Daniel Rauh; Thomas Zander; Roland T Ullrich; H Christian Reinhardt; Francois Ringeisen; Reinhard Büttner; Lukas C Heukamp; Jürgen Wolf; Roman K Thomas
Journal: Cancer Discov Date: 2013-12-03 Impact factor: 39.397

8. A genomics-based classification of human lung tumors.

Authors:
Journal: Sci Transl Med Date: 2013-10-30 Impact factor: 17.956

9. Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.

Authors: Amit Dutt; Alex H Ramos; Peter S Hammerman; Craig Mermel; Jeonghee Cho; Tanaz Sharifnia; Ajit Chande; Kumiko Elisa Tanaka; Nicolas Stransky; Heidi Greulich; Nathanael S Gray; Matthew Meyerson
Journal: PLoS One Date: 2011-06-07 Impact factor: 3.240

10. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas.

Authors: Adam J Bass; Hideo Watanabe; Craig H Mermel; Soyoung Yu; Sven Perner; Roel G Verhaak; So Young Kim; Leslie Wardwell; Pablo Tamayo; Irit Gat-Viks; Alex H Ramos; Michele S Woo; Barbara A Weir; Gad Getz; Rameen Beroukhim; Michael O'Kelly; Amit Dutt; Orit Rozenblatt-Rosen; Piotr Dziunycz; Justin Komisarof; Lucian R Chirieac; Christopher J Lafargue; Veit Scheble; Theresia Wilbertz; Changqing Ma; Shilpa Rao; Hiroshi Nakagawa; Douglas B Stairs; Lin Lin; Thomas J Giordano; Patrick Wagner; John D Minna; Adi F Gazdar; Chang Qi Zhu; Marcia S Brose; Ivan Cecconello; Ulysses Ribeiro; Suely K Marie; Olav Dahl; Ramesh A Shivdasani; Ming-Sound Tsao; Mark A Rubin; Kwok K Wong; Aviv Regev; William C Hahn; David G Beer; Anil K Rustgi; Matthew Meyerson
Journal: Nat Genet Date: 2009-10-04 Impact factor: 38.330

2 in total

Review 1. Synthetic lethality in lung cancer and translation to clinical therapies.

Authors: Ada W Y Leung; Tanya de Silva; Marcel B Bally; William W Lockwood
Journal: Mol Cancer Date: 2016-09-29 Impact factor: 27.401

2. Prognostic implications of FGFR1 and MYC status in esophageal squamous cell carcinoma.

Authors: Dohee Kwon; Ji Yun Yun; Bhumsuk Keam; Young Tae Kim; Yoon Kyung Jeon
Journal: World J Gastroenterol Date: 2016-11-28 Impact factor: 5.742

2 in total