BACKGROUND: In acute myeloid leukemia (AML), CXCR4 expression has been correlated with leukocytosis and prognosis. METHODS: We quantified CXCR4 expression by flow cytometry on leukemic cells in 142 AML patients. RESULTS: We confirm a correlation between high CXCR4 expression and leukemic burden. Furthermore, we documented a correlation with platelet count, dysplastic megakaryopoiesis, hepato-splenomegaly and extra-hematological disease. NPM1-mutated AML displayed a significantly higher intensity of CXCR4 compared to NPM1-wt cases: it is conceivable its clinical phenotype to be driven by high CXCR4 expression. CONCLUSIONS: CXCR4 expression resulted in an independent prognostic factor. Our data support CXCR4 targeting as a potential therapeutic strategy.
BACKGROUND: In acute myeloid leukemia (AML), CXCR4 expression has been correlated with leukocytosis and prognosis. METHODS: We quantified CXCR4 expression by flow cytometry on leukemic cells in 142 AMLpatients. RESULTS: We confirm a correlation between high CXCR4 expression and leukemic burden. Furthermore, we documented a correlation with platelet count, dysplastic megakaryopoiesis, hepato-splenomegaly and extra-hematological disease. NPM1-mutated AML displayed a significantly higher intensity of CXCR4 compared to NPM1-wt cases: it is conceivable its clinical phenotype to be driven by high CXCR4 expression. CONCLUSIONS:CXCR4 expression resulted in an independent prognostic factor. Our data support CXCR4 targeting as a potential therapeutic strategy.
Authors: A F O Costa; D L Menezes; L H S Pinheiro; A F Sandes; M A P Nunes; D P Lyra Junior; D M Schimieguel Journal: Sci Rep Date: 2017-06-23 Impact factor: 4.379
Authors: Jade Jaffar; Kate Griffiths; Sara Oveissi; Mubing Duan; Michael Foley; Ian Glaspole; Karen Symons; Louise Organ; Glen Westall Journal: Respir Res Date: 2020-08-26