Luisa Fofi 1 , Valerio Orlandi 2 , Nicola Vanacore 3 , Maria C Mizzoni 2 , Alba Rosa 2 , Cinzia Aurilia 1 , Gabriella Egeo 1 , Pietro Casella 2 , Piero Barbanti 4 Show Affiliations »
Abstract
BACKGROUND: Headache is one of the most common symptoms after cocaine use. METHODS: We investigated headache frequency and characteristics and the correlation between headache and acute cocaine intake in a cross-sectional study in a consecutive series of chronic cocaine users. RESULTS: Participation rate was 94.1%. Of the 80 subjects enrolled, 72 (90%) reported current headaches, in most cases migraine or probable migraine without aura. Of these 72, 29 (40.3%) had a headache history, whereas 43 (59.7%) reported de novo headache after beginning to use cocaine. After acute cocaine use, a large percentage of users reported headache attacks: 86.2% of previous headache sufferers (migraine or probable migraine without aura in all cases) and 93% of de novo headache sufferers (migraine/probable migraine without aura = 35; episodic tension-type headache = three patients; cocaine-induced headache= two patients). Most subjects reported that when they used cocaine headaches worsened. CONCLUSION: Chronic cocaine use frequently seems to worsen or induce headache with migraine or migraine-like characteristics, probably owing to a serotoninergic and dopaminergic system impairment. In headache sufferers, especially those with migraine headaches, clinicians should enquire into possible cocaine use. © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
BACKGROUND: Headache is one of the most common symptoms after cocaine use. METHODS: We investigated headache frequency and characteristics and the correlation between headache and acute cocaine intake in a cross-sectional study in a consecutive series of chronic cocaine users. RESULTS: Participation rate was 94.1%. Of the 80 subjects enrolled, 72 (90%) reported current headaches , in most cases migraine or probable migraine without aura . Of these 72, 29 (40.3%) had a headache history, whereas 43 (59.7%) reported de novo headache after beginning to use cocaine . After acute cocaine use, a large percentage of users reported headache attacks: 86.2% of previous headache sufferers (migraine or probable migraine without aura in all cases) and 93% of de novo headache sufferers (migraine /probable migraine without aura = 35; episodic tension-type headache = three patients ; cocaine -induced headache = two patients ). Most subjects reported that when they used cocaine headaches worsened. CONCLUSION: Chronic cocaine use frequently seems to worsen or induce headache with migraine or migraine -like characteristics, probably owing to a serotoninergic and dopaminergic system impairment . In headache sufferers, especially those with migraine headaches , clinicians should enquire into possible cocaine use. © International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
Entities: Chemical
Disease
Species
Keywords:
Headache; chronic; cocaine; cocaine-induced headache; disability; migraine
Year: 2014
PMID： 24500813 DOI： 10.1177/0333102414520764
Source DB: PubMed Journal: Cephalalgia ISSN： 0333-1024 Impact factor: 6.292