Literature DB >> 2450037

Evidence for neurokinin-3 receptor-mediated tachykinin release in the guinea-pig ileum.

S Guard1, S P Watson.   

Abstract

Contraction of longitudinal muscle strips of the guinea-pig ileum induced by the selective NK3 receptor agonist, succ-[Asp6,MePhe8]SP-(6-11) (senktide), were completely inhibited by tetrodotoxin and partially blocked by atropine. The atropine-resistant contraction was markedly reduced if the smooth muscle tachykinin receptors were either desensitized with the selective NK1 agonist substance P methyl ester, or blocked with the tachykinin receptor antagonist [D-Pro4,D-Trp7,9,10]SP-(4-11). These results suggest that activation of NK3 receptors on enteric neurones results in acetylcholine and tachykinin release.

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Year:  1987        PMID： 2450037     DOI： 10.1016/0014-2999(87)90398-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  17 in total

1.  Differential role of tachykinin NK3 receptors on cholinergic excitatory neurotransmission in the mouse stomach and small intestine.

Authors:  J G De Man; B Y De Winter; H U De Schepper; A G Herman; P A Pelckmans
Journal:  Br J Pharmacol       Date:  2008-09-22       Impact factor: 8.739

2.  Effect of SR 142801 on nitric oxide-dependent and independent responses to tachykinin NK3 receptor agonists in isolated guinea-pig colon.

Authors:  S Giuliani; C A Maggi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-11       Impact factor: 3.000

3.  Pharmacological analysis of [3H]-senktide binding to NK3 tachykinin receptors in guinea-pig ileum longitudinal muscle-myenteric plexus and cerebral cortex membranes.

Authors:  S Guard; S P Watson; J E Maggio; H P Too; K J Watling
Journal:  Br J Pharmacol       Date:  1990-04       Impact factor: 8.739

4.  Human isolated ileum: motor responses of the circular muscle to electrical field stimulation and exogenous neuropeptides.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani; D Turini; G Barbanti; A Giachetti; A Meli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-03       Impact factor: 3.000

5.  Contrasting effects of tachykinins and guanethidine on the acetylcholine output stimulated by nicotine from guinea-pig bladder [corrected].

Authors:  M Shinkai; I Takayanagi; T Kato
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

6.  Pharmacological characterization of the contractile responses to angiotensin analogues in guinea-pig isolated longitudinal muscle of small intestine.

Authors:  A B Hawcock; J C Barnes
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

7.  Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract.

Authors:  E F Grady; P Baluk; S Böhm; P D Gamp; H Wong; D G Payan; J Ansel; A L Portbury; J B Furness; D M McDonald; N W Bunnett
Journal:  J Neurosci       Date:  1996-11-01       Impact factor: 6.167

8.  Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors.

Authors:  L Bartho; P Santicioli; R Patacchini; C A Maggi
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

9.  Pharmacological characterisation of neurokinin receptors mediating anion secretion in rat descending colon mucosa.

Authors:  H M Cox; I R Tough; K Grayson; S Yarrow
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-08       Impact factor: 3.000

10.  Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.

Authors:  K McConalogue; C U Corvera; P D Gamp; E F Grady; N W Bunnett
Journal:  Mol Biol Cell       Date:  1998-08       Impact factor: 4.138
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