Sofus C Larsen1, Lars Ängquist, Tarunveer Singh Ahluwalia, Tea Skaaby, Nina Roswall, Anne Tjønneland, Jytte Halkjær, Kim Overvad, Oluf Pedersen, Torben Hansen, Allan Linneberg, Lise Lotte N Husemoen, Ulla Toft, Berit L Heitmann, Thorkild Ia Sørensen. 1. Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospitals, the Capital Region, Copenhagen, Denmark (SCL, LÄ, BLH, and TIAS); the Novo Nordisk Foundation Center for Basic Metabolic Research, Section on Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (TSA, OP, TH, and TIAS); the Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark (TS, AL, LLNH, UT, and BLH); the Danish Cancer Society Research Center, Copenhagen, Denmark (NR, AT, and JH); the Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark (KO); the Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark (KO); the National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark (BLH); and the Boden Institute of Obesity, Nutrition, Exercise and Eating Disorders, The University of Sydney, Sydney, Australia (BLH).
Abstract
BACKGROUND: Studies indicate an effect of dietary calcium on change in body weight (BW) and waist circumference (WC), but the results are inconsistent. Furthermore, a relation could depend on genetic predisposition to obesity. OBJECTIVE: The objective was to examine whether genetic predisposition to higher body mass index (BMI), WC, or waist-hip ratio (WHR) interacts with dietary calcium in relation to subsequent annual change in BW (ΔBW) and WC (ΔWC). DESIGN: The study was based on 7569 individuals from the MONItoring trends and determinants of CArdiovascular disease Study, a sample from the Danish Diet, Cancer and Health Study and the INTER99 study, with information on diet; 54 single-nucleotide polymorphisms (SNPs) associated with BMI, WC, or WHR adjusted for BMI; and potential confounders. The SNPs were combined in 4 scores as indicators of genetic predisposition; all SNPs in a general score and a score for each of 3 phenotypes: BMI, WC, and WHR. Linear regression was used to examine the association between calcium intake and ΔBW or ΔWC adjusted for concurrent ΔBW. SNP score × calcium interactions were examined by adding product terms to the models. RESULTS: We found a significant ΔBW of -0.076 kg (P = 0.021; 95% CI: -0.140, -0.012) per 1000 mg Ca. No significant association was observed between dietary calcium and ΔWC. In the analyses with ΔBW as outcome, we found no significant interactions between the developed predisposition scores and calcium. However, we found a significant interaction between a score of 6 WC-associated SNPs and calcium in relation to ΔWC. Each risk allele was associated with a ΔWC of -0.043 cm (P = 0.038; 95% CI: -0.083, -0.002) per 1000 mg Ca. CONCLUSIONS: Our study suggests that dietary calcium relates weakly to BW loss. We found no evidence of a general association between calcium and ΔWC, but calcium may reduce WC among people genetically predisposed to a high WC. However, further replication of this finding is needed.
RCT Entities:
BACKGROUND: Studies indicate an effect of dietary calcium on change in body weight (BW) and waist circumference (WC), but the results are inconsistent. Furthermore, a relation could depend on genetic predisposition to obesity. OBJECTIVE: The objective was to examine whether genetic predisposition to higher body mass index (BMI), WC, or waist-hip ratio (WHR) interacts with dietary calcium in relation to subsequent annual change in BW (ΔBW) and WC (ΔWC). DESIGN: The study was based on 7569 individuals from the MONItoring trends and determinants of CArdiovascular disease Study, a sample from the Danish Diet, Cancer and Health Study and the INTER99 study, with information on diet; 54 single-nucleotide polymorphisms (SNPs) associated with BMI, WC, or WHR adjusted for BMI; and potential confounders. The SNPs were combined in 4 scores as indicators of genetic predisposition; all SNPs in a general score and a score for each of 3 phenotypes: BMI, WC, and WHR. Linear regression was used to examine the association between calcium intake and ΔBW or ΔWC adjusted for concurrent ΔBW. SNP score × calcium interactions were examined by adding product terms to the models. RESULTS: We found a significant ΔBW of -0.076 kg (P = 0.021; 95% CI: -0.140, -0.012) per 1000 mg Ca. No significant association was observed between dietary calcium and ΔWC. In the analyses with ΔBW as outcome, we found no significant interactions between the developed predisposition scores and calcium. However, we found a significant interaction between a score of 6 WC-associated SNPs and calcium in relation to ΔWC. Each risk allele was associated with a ΔWC of -0.043 cm (P = 0.038; 95% CI: -0.083, -0.002) per 1000 mg Ca. CONCLUSIONS: Our study suggests that dietary calcium relates weakly to BW loss. We found no evidence of a general association between calcium and ΔWC, but calcium may reduce WC among people genetically predisposed to a high WC. However, further replication of this finding is needed.
Authors: So Young Bu; Mi Ja Choi; Da Seul Choi; You-Mi Jung; In-Sil Jang; Narae Yang; Kirang Kim; Clara Yongjoo Park Journal: Nutr Res Pract Date: 2022-02-14 Impact factor: 1.992
Authors: Mikkel Z Ankarfeldt; Sofus C Larsen; Lars Ängquist; Lise Lotte N Husemoen; Nina Roswall; Kim Overvad; Marianne Uhre Jakobsen; Jytte Halkjær; Anne Tjønneland; Allan Linneberg; Ulla Toft; Torben Hansen; Oluf Pedersen; Berit L Heitmann; Arne Astrup; Thorkild I A Sørensen Journal: PLoS One Date: 2014-10-28 Impact factor: 3.240
Authors: Jeanett F Rohde; Lars Ängquist; Sofus C Larsen; Janne S Tolstrup; Lise Lotte N Husemoen; Allan Linneberg; Ulla Toft; Kim Overvad; Jytte Halkjær; Anne Tjønneland; Torben Hansen; Oluf Pedersen; Thorkild I A Sørensen; Berit L Heitmann Journal: Nutr J Date: 2017-08-25 Impact factor: 3.271
Authors: Sofus C Larsen; Lars Angquist; Tarunveer Singh Ahluwalia; Tea Skaaby; Nina Roswall; Anne Tjønneland; Jytte Halkjær; Kim Overvad; Oluf Pedersen; Torben Hansen; Allan Linneberg; Lise Lotte N Husemoen; Ulla Toft; Berit L Heitmann; Thorkild I A Sørensen Journal: Nutr J Date: 2014-05-03 Impact factor: 3.271
Authors: Sofus C Larsen; Lars Ängquist; Max Moldovan; Ville Huikari; Sylvain Sebert; Alana Cavadino; Tarunveer Singh Ahluwalia; Tea Skaaby; Allan Linneberg; Lise Lotte N Husemoen; Ulla Toft; Oluf Pedersen; Torben Hansen; Karl-Heinz Herzig; Marjo-Riitta Jarvelin; Chris Power; Elina Hyppönen; Berit L Heitmann; Thorkild I A Sørensen Journal: PLoS One Date: 2016-04-14 Impact factor: 3.240
Authors: Sofus C Larsen; Lars Ängquist; Charles Laurin; Camilla S Morgen; Marianne U Jakobsen; Lavinia Paternoster; George Davey Smith; Sjurdur F Olsen; Thorkild I A Sørensen; Ellen A Nohr Journal: PLoS One Date: 2016-03-01 Impact factor: 3.240