| Literature DB >> 2449935 |
D Langui1, B H Anderton, J P Brion, J Ulrich.
Abstract
Neurofilamentous tangles have been induced by aluminium chloride in rat brain neurons cultivated on astroglial feeder layers. Monoclonal antibodies to neurofilaments were found to stain these aluminium-induced tangles. Immunostaining of these structures with anti-paired helical filament serum was always negative, though good staining of neuronal perikarya was achieved. This observation supports the hypothesis that aluminium-induced tangles are made up of neurofilament proteins. These tangles appear to be distinct immunochemically from Alzheimer-paired helical filaments.Entities:
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Year: 1988 PMID： 2449935 DOI： 10.1016/0006-8993(88)91324-8
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252