Literature DB >> 24498540

STAT5 in hematopoietic stem cell biology and transplantation.

Zhengqi Wang1, Kevin D Bunting1.   

Abstract

Signal transducer and activator of transcription 5 (STAT5) regulates normal lympho-myeloid development through activation downstream of early-acting cytokines, their receptors, and Janus kinases (JAKs). Despite a general understanding of the role of STAT5 in hematopoietic stem cell (HSC) proliferation, survival, and self-renewal, the transcriptional targets and mechanisms of gene regulation that control multi-lineage engraftment following transplantation for the most part remain to be understood. In this review, we focus on the role of STAT5 in HSC transplantation and recent developments toward identifying the relevant downstream target genes and their role as part of a pleiotropic STAT5 mediated signaling response.

Entities:  

Keywords:  JAK-STAT; cytokine signaling; engraftment; hematopoiesis; quiescence; self-renewal; stem cell; transplantation

Year:  2013        PMID： 24498540      PMCID： PMC3906416          DOI： 10.4161/jkst.27159

Source DB:  PubMed          Journal:  JAKSTAT        ISSN： 2162-3988


  96 in total

1.  Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.

Authors:  Katrin Friedbichler; Marc A Kerenyi; Boris Kovacic; Geqiang Li; Andrea Hoelbl; Saliha Yahiaoui; Veronika Sexl; Ernst W Müllner; Sabine Fajmann; Sabine Cerny-Reiterer; Peter Valent; Hartmut Beug; Fabrice Gouilleux; Kevin D Bunting; Richard Moriggl
Journal:  Blood       Date:  2010-05-27       Impact factor: 22.113

2.  Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation.

Authors:  Albertus T J Wierenga; Edo Vellenga; Jan Jacob Schuringa
Journal:  Blood       Date:  2010-03-25       Impact factor: 22.113

3.  The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells.

Authors:  E Sitnicka; N Lin; G V Priestley; N Fox; V C Broudy; N S Wolf; K Kaushansky
Journal:  Blood       Date:  1996-06-15       Impact factor: 22.113

4.  Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways.

Authors:  Keita Kirito; Tomoko Watanabe; Ken-ichi Sawada; Hitoshi Endo; Keiya Ozawa; Norio Komatsu
Journal:  J Biol Chem       Date:  2001-12-27       Impact factor: 5.157

Review 5.  Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior.

Authors:  Timm Schroeder
Journal:  Cell Stem Cell       Date:  2010-03-05       Impact factor: 24.633

6.  Thrombopoietin induces tyrosine phosphorylation of a common beta subunit of GM-CSF receptor and its association with Stat5 in TF-1/TPO cells.

Authors:  J Ooi; A Tojo; S Asano; Y Sato; Y Oka
Journal:  Biochem Biophys Res Commun       Date:  1998-05-08       Impact factor: 3.575

7.  Stat5a is mandatory for adult mammary gland development and lactogenesis.

Authors:  X Liu; G W Robinson; K U Wagner; L Garrett; A Wynshaw-Boris; L Hennighausen
Journal:  Genes Dev       Date:  1997-01-15       Impact factor: 11.361

8.  β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis.

Authors:  Thomas Oellerich; Mark F Oellerich; Michael Engelke; Silvia Münch; Sebastian Mohr; Marika Nimz; He-Hsuan Hsiao; Jasmin Corso; Jing Zhang; Hanibal Bohnenberger; Tobias Berg; Michael A Rieger; Jürgen Wienands; Gesine Bug; Christian Brandts; Henning Urlaub; Hubert Serve
Journal:  Blood       Date:  2013-03-18       Impact factor: 22.113

9.  Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.

Authors:  Bing-Mei Zhu; Keunsoo Kang; Ji Hoon Yu; Weiping Chen; Harold E Smith; Daeyoup Lee; Hong-Wei Sun; Lai Wei; Lothar Hennighausen
Journal:  Nucleic Acids Res       Date:  2012-02-08       Impact factor: 16.971

10.  Single-cell STAT5 signal transduction profiling in normal and leukemic stem and progenitor cell populations reveals highly distinct cytokine responses.

Authors:  Lina Han; Albertus T J Wierenga; Marjan Rozenveld-Geugien; Kim van de Lande; Edo Vellenga; Jan Jacob Schuringa
Journal:  PLoS One       Date:  2009-11-24       Impact factor: 3.240
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  14 in total

Review 1.  Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Authors:  Han-Yu Shih; Giuseppe Sciumè; Amanda C Poholek; Golnaz Vahedi; Kiyoshi Hirahara; Alejandro V Villarino; Michael Bonelli; Remy Bosselut; Yuka Kanno; Stefan A Muljo; John J O'Shea
Journal:  Immunol Rev       Date:  2014-09       Impact factor: 12.988

Review 2.  Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology.

Authors:  Carlota Recio; Borja Guerra; Miguel Guerra-Rodríguez; Haidée Aranda-Tavío; Patricia Martín-Rodríguez; Mercedes de Mirecki-Garrido; Yeray Brito-Casillas; José M García-Castellano; Ana Estévez-Braun; Leandro Fernández-Pérez
Journal:  Oncogene       Date:  2019-02-19       Impact factor: 9.867

3.  The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma.

Authors:  Alexandra Keller; Bettina Wingelhofer; Barbara Peter; Karin Bauer; Daniela Berger; Susanne Gamperl; Martin Reifinger; Sabine Cerny-Reiterer; Richard Moriggl; Michael Willmann; Peter Valent; Emir Hadzijusufovic
Journal:  Vet Comp Oncol       Date:  2017-04-11       Impact factor: 2.613

Review 4.  JAK-STAT in Early Hematopoiesis and Leukemia.

Authors:  Eirini Sofia Fasouli; Eleni Katsantoni
Journal:  Front Cell Dev Biol       Date:  2021-05-14

5.  Emancipation from transcriptional latency: unphosphorylated STAT5 as guardian of hematopoietic differentiation.

Authors:  Thomas Decker
Journal:  EMBO J       Date:  2016-02-18       Impact factor: 11.598

6.  Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations.

Authors:  Zhengqi Wang; Kevin D Bunting
Journal:  Oncotarget       Date:  2017-04-04

7.  GRAM domain-containing protein 1A (GRAMD1A) promotes the expansion of hepatocellular carcinoma stem cell and hepatocellular carcinoma growth through STAT5.

Authors:  Binsheng Fu; Wei Meng; Hui Zhao; Bing Zhang; Hui Tang; Ying Zou; Jia Yao; Heping Li; Tong Zhang
Journal:  Sci Rep       Date:  2016-09-02       Impact factor: 4.379

8.  Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML.

Authors:  Sheng Li; Xiaowen Chen; Jiahui Wang; Cem Meydan; Jacob L Glass; Alan H Shih; Ruud Delwel; Ross L Levine; Christopher E Mason; Ari M Melnick
Journal:  Cancer Discov       Date:  2020-09-16       Impact factor: 38.272

9.  BMP signalling differentially regulates distinct haematopoietic stem cell types.

Authors:  Mihaela Crisan; Parham Solaimani Kartalaei; Chris S Vink; Chris Vink; Tomoko Yamada-Inagawa; Karine Bollerot; Wilfred van IJcken; Reinier van der Linden; Susana M Chuva de Sousa Lopes; Rui Monteiro; Christine Mummery; Elaine Dzierzak
Journal:  Nat Commun       Date:  2015-08-18       Impact factor: 14.919

10.  STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling.

Authors:  Nadine Haetscher; Yonatan Feuermann; Susanne Wingert; Maike Rehage; Frederic B Thalheimer; Christian Weiser; Hanibal Bohnenberger; Klaus Jung; Timm Schroeder; Hubert Serve; Thomas Oellerich; Lothar Hennighausen; Michael A Rieger
Journal:  Nat Commun       Date:  2015-11-25       Impact factor: 14.919
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