BACKGROUND: The acidity of lidocaine preparations is believed to contribute to the pain of local anesthetic injection. OBJECTIVE: To investigate the effect of buffering lidocaine on the pain of injection and duration of anesthetic effect. METHODS: A double-blind, randomized trial involving 44 healthy volunteers was conducted. The upper lip was injected with a solution of: lidocaine 1% (Xylocaine, AstraZeneca, Canada, Inc) with epinephrine; and lidocaine 1% with epinephrine and 8.4% sodium bicarbonate. Volunteers reported pain of injection and duration of anesthetic effect. RESULTS: Twenty-six participants found the unbuffered solution to be more painful. Fifteen participants found the buffered solution to be more painful; the difference was not statistically significant. Twenty-one volunteers reported duration of anesthetic effect. The buffered solution provided longer anesthetic effect than the unbuffered solution (P=0.004). CONCLUSION: Although buffering increased the duration of lidocaine's anesthetic effect in this particular model, a decrease in the pain of the injection was not demonstrated, likely due to limitations of the study.
RCT Entities:
BACKGROUND: The acidity of lidocaine preparations is believed to contribute to the pain of local anesthetic injection. OBJECTIVE: To investigate the effect of buffering lidocaine on the pain of injection and duration of anesthetic effect. METHODS: A double-blind, randomized trial involving 44 healthy volunteers was conducted. The upper lip was injected with a solution of: lidocaine 1% (Xylocaine, AstraZeneca, Canada, Inc) with epinephrine; and lidocaine 1% with epinephrine and 8.4% sodium bicarbonate. Volunteers reported pain of injection and duration of anesthetic effect. RESULTS: Twenty-six participants found the unbuffered solution to be more painful. Fifteen participants found the buffered solution to be more painful; the difference was not statistically significant. Twenty-one volunteers reported duration of anesthetic effect. The buffered solution provided longer anesthetic effect than the unbuffered solution (P=0.004). CONCLUSION: Although buffering increased the duration of lidocaine's anesthetic effect in this particular model, a decrease in the pain of the injection was not demonstrated, likely due to limitations of the study.
Entities:
Keywords:
Lidocaine; Local anesthesia; Pain; Sodium bicarbonate
Authors: Carrine A Burns; Georgette Ferris; Changyong Feng; Jennifer Z Cooper; Marc D Brown Journal: J Am Acad Dermatol Date: 2006-01 Impact factor: 11.527
Authors: Mary-Ellen Hogan; Sondra vanderVaart; Kumar Perampaladas; Márcio Machado; Thomas R Einarson; Anna Taddio Journal: Ann Emerg Med Date: 2011-02-12 Impact factor: 5.721