| Literature DB >> 24497354 |
Aaron S Miller1, Max L Tejada, Hélène Gazzano-Santoro.
Abstract
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a relevant characteristic to measure for a number of therapeutic monoclonal antibodies (mAbs) under development. ADCC is a mechanism by which antibody-opsonized, infected, or cancerous cells are destroyed by FcγRIII (CD16)-expressing effector cells. Here we describe three methods that can be used to quantify the ADCC activity of mAbs by measuring distinct aspects of the ADCC mechanism.Entities:
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Year: 2014 PMID： 24497354 DOI： 10.1007/978-1-4939-0326-9_5
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745