Yong Sang Lee1, Soon Won Hong, Hang-Seok Chang, Cheong Soo Park. 1. Thyroid Cancer Center, Departments of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul, 135-720, Korea, medilys@yuhs.ac.
Abstract
BACKGROUND: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. OBJECTIVE: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. MATERIALS AND METHODS: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. RESULTS: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. CONCLUSIONS: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.
BACKGROUND: Although psammomatous calcification is a characteristic pathologic feature of papillary thyroid carcinoma (PTC), the clinical meaning of histologically determined scattered psammomatous calcifications around PTC is unknown. OBJECTIVE: The aim of this study was to evaluate the clinical significance of scattered psammomatous calcifications around PTC. MATERIALS AND METHODS: Between January 2009 and July 2009, a total of 546 patients who underwent total thyroidectomy for PTC were enrolled. They were classified into two groups: patients with scattered psammomatous calcifications and patients without psammomatous calcifications. The clinical findings, preoperative diagnostic findings, and histopathologic features were compared between the two groups. RESULTS: Scattered psammomatous calcifications around PTC were found in 209 patients (38 %), and mostly in younger patients (p = 0.007), those with infiltrative tumor margin (p = 0.022), those with capsule invasion (p = 0.013), and those with lymph node metastasis (p < 0.001). No statistical significance was found in gender, tumor size, multiplicity, and coexisting lymphocytic thyroiditis. CONCLUSIONS: Although further studies with large-scale, long-term follow-up will be necessary to validate the relationship between scattered psammomatous calcifications and prognosis, scattered psammomatous calcification around PTC may have correlations with the aggressiveness of the PTC.
Authors: Dilip K Das; Mrinmay K Mallik; Bahiyah E Haji; Mahmoud S Ahmed; Mariam Al-Shama'a; Bushra Al-Ayadhy; Sara S George; Sitara A Sathar; Thamradeen A Junaid Journal: Diagn Cytopathol Date: 2004-12 Impact factor: 1.582
Authors: S Ortiz; J M Rodríguez; T Soria; D Pérez-Flores; A Piñero; J Moreno; P Parrilla Journal: Otolaryngol Head Neck Surg Date: 2001-03 Impact factor: 3.497
Authors: P A Singer; D S Cooper; G H Daniels; P W Ladenson; F S Greenspan; E G Levy; L E Braverman; O H Clark; I R McDougall; K V Ain; S G Dorfman Journal: Arch Intern Med Date: 1996-10-28