Literature DB >> 24496380

Single-point mutation detection in RNA extracts using gold nanoparticles modified with hydrophobic molecular beacon-like structures.

Alfonso Latorre1, Christian Posch, Yolanda Garcimartín, Susana Ortiz-Urda, Álvaro Somoza.   

Abstract

Gold nanoparticles functionalized with oligonucleotides that bear a cholesterol group are used as gene sensors. The hydrophobic molecule is buried inside the nanostructure but when the complementary RNA sequence is present the structure unfolds exposing the cholesterol group to the water molecules. This rearrangement leads to the aggregation of the nanostructures.

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Year:  2014        PMID： 24496380      PMCID： PMC4339280          DOI： 10.1039/c3cc47862a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  20 in total

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Journal:  Bioconjug Chem       Date:  2010-06-16       Impact factor: 4.774

4.  Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes.

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Review 5.  Nanostructures in biodiagnostics.

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Review 9.  Gold nanoparticles for biology and medicine.

Authors:  David A Giljohann; Dwight S Seferos; Weston L Daniel; Matthew D Massich; Pinal C Patel; Chad A Mirkin
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  6 in total

1.  Detection of GNAQ mutations and reduction of cell viability in uveal melanoma cells with functionalized gold nanoparticles.

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Journal:  Biomed Microdevices       Date:  2015-02       Impact factor: 2.838

Review 2.  Rationally designed molecular beacons for bioanalytical and biomedical applications.

Authors:  Jing Zheng; Ronghua Yang; Muling Shi; Cuichen Wu; Xiaohong Fang; Yinhui Li; Jishan Li; Weihong Tan
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Review 3.  Liquid biopsy for detection of actionable oncogenic mutations in human cancers and electric field induced release and measurement liquid biopsy (eLB).

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Journal:  Analyst       Date:  2016-01-21       Impact factor: 4.616

Review 4.  Emerging technologies for salivaomics in cancer detection.

Authors:  Karolina Elżbieta Kaczor-Urbanowicz; Carmen Martín Carreras-Presas; Tadeusz Kaczor; Michael Tu; Fang Wei; Franklin Garcia-Godoy; David T W Wong
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6.  BioCode gold-nanobeacon for the detection of fusion transcripts causing chronic myeloid leukemia.

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  6 in total

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