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Literature DB >> 2449623

Substance P modulates the release of locally synthesized nerve growth factor from rat saphenous nerve neuroma.

D M White¹, P Ehrhard, M Hardung, D K Meyer, M Zimmermann, U Otten.

Abstract

In saphenous nerve neuromata of adult rats a long-term increase of immunoreactive nerve growth factor (irNGF) was detected after nerve transection. The occurrence of messenger RNA encoding NGF (NGF mRNA) in these proximal nerve stumps indicates local biosynthesis of NGF. In situ superfusion of neuromata revealed a constant release of irNGF which was significantly reduced by substance P (SP) but not affected by calcitonin gene related peptide (CGRP). We therefore suggest that SP may modulate the availability of NGF in the microenvironment of the regenerating nerve fiber endings.

Entities: Disease Gene Species

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Year: 1987 PMID： 2449623 DOI： 10.1007/bf00169319

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

21 in total

1. Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P.

Authors: Y Lee; K Takami; Y Kawai; S Girgis; C J Hillyard; I MacIntyre; P C Emson; M Tohyama
Journal: Neuroscience Date: 1985-08 Impact factor: 3.590

2. In vivo and in vitro actions of mammalian tachykinins.

Authors: U Holzer-Petsche; E Schimek; R Amann; F Lembeck
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1985-08 Impact factor: 3.000

3. Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex.

Authors: G Weskamp; H P Lorez; H H Keller; U Otten
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1986-12 Impact factor: 3.000

4. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

Authors: D A Melton; P A Krieg; M R Rebagliati; T Maniatis; K Zinn; M R Green
Journal: Nucleic Acids Res Date: 1984-09-25 Impact factor: 16.971

9. Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons.

Authors: S A Shehab; M E Atkinson
Journal: Brain Res Date: 1986-04-30 Impact factor: 3.252

10. An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissues.

Authors: G Weskamp; U Otten
Journal: J Neurochem Date: 1987-06 Impact factor: 5.372

1 in total

Review 1. Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity.

Authors: J P Huston; R U Hasenöhrl; F Boix; P Gerhardt; R K Schwarting
Journal: Psychopharmacology (Berl) Date: 1993 Impact factor: 4.530

1 in total

Substance P modulates the release of locally synthesized nerve growth factor from rat saphenous nerve neuroma.

1. Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P.

2. In vivo and in vitro actions of mammalian tachykinins.

3. Cholinergic but not monoaminergic denervation increases nerve growth factor content in the adult rat hippocampus and cerebral cortex.

4. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter.

5. A reproducible microanalytical method for the detection of specific RNA sequences by dot-blot hybridization.

Review 6. Coexistence of peptides with classical neurotransmitters.

7. Release of histamine by neuropeptides from the perfused rat hindquarter.

8. Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor.

9. Vasoactive intestinal polypeptide (VIP) increases in the spinal cord after peripheral axotomy of the sciatic nerve originate from primary afferent neurons.

10. An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissues.

Review 1. Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity.