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Literature DB >> 2449606

Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells.

Abstract

The mechanism of transcriptional activation of human leukocyte antigen class I genes by gamma interferon and 5-azacytidine was studied in K562 human leukemia cells. Nuclear run-on transcription assays with various protein and RNA synthesis inhibitors yield evidence for both stimulation of a positive regulatory factor and inhibition of an mRNA that codes for a labile repressor. A novel mechanism is proposed to explain how 5-azacytidine can activate repressed genes without affecting DNA methylation.

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Year: 1987 PMID： 2449606 PMCID： PMC368146 DOI： 10.1128/mcb.7.12.4572-4575.1987

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

35 in total

Review 1. Altering gene expression with 5-azacytidine.

Authors: P A Jones
Journal: Cell Date: 1985-03 Impact factor: 41.582

2. Murine cells expressing an HLA molecule are specifically lysed by HLA-restricted antiviral human T cells.

Authors: E Gomard; B Begue; S Sodoyer; J L Maryanski; B R Jordan; J P Levy
Journal: Nature Date: 1986 Jan 9-15 Impact factor: 49.962

3. Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

Authors: A K Sood; D Pereira; S M Weissman
Journal: Proc Natl Acad Sci U S A Date: 1981-01 Impact factor: 11.205

4. Transcriptional induction of two genes in human cells by beta interferon.

Authors: A C Larner; G Jonak; Y S Cheng; B Korant; E Knight; J E Darnell
Journal: Proc Natl Acad Sci U S A Date: 1984-11 Impact factor: 11.205

5. Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells.

Authors: D Wallach; M Fellous; M Revel
Journal: Nature Date: 1982-10-28 Impact factor: 49.962

6. Differential gamma-interferon response of human colon carcinoma cells: inhibition of proliferation and modulation of immunogenicity as independent effects of gamma-interferon on tumor cell growth.

Authors: K Pfizenmaier; H Bartsch; P Scheurich; B Seliger; U Ucer; K Vehmeyer; G A Nagel
Journal: Cancer Res Date: 1985-08 Impact factor: 12.701

1. Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.

Authors: M E Lambert; Z A Ronai; I B Weinstein; J I Garrels
Journal: Mol Cell Biol Date: 1989-02 Impact factor: 4.272

1 in total

Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells.

Review 1. Altering gene expression with 5-azacytidine.

2. Murine cells expressing an HLA molecule are specifically lysed by HLA-restricted antiviral human T cells.

3. Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

4. Transcriptional induction of two genes in human cells by beta interferon.

5. Preferential effect of gamma interferon on the synthesis of HLA antigens and their mRNAs in human cells.

6. Differential gamma-interferon response of human colon carcinoma cells: inhibition of proliferation and modulation of immunogenicity as independent effects of gamma-interferon on tumor cell growth.

7. Cellular differentiation, cytidine analogs and DNA methylation.

8. Striking paucity of HLA-A, B, C and beta 2-microglobulin on human neuroblastoma cell lines.

9. Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation.

10. Modulation of the tumorigenicity of human adenovirus-12-transformed cells by interferon.

1. Enhancement of major histocompatibility class I protein synthesis by DNA damage in cultured human fibroblasts and keratinocytes.