Literature DB >> 24495954

Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer.

Yunbao Pan1, Huiling Yang2, Francois X Claret3.   

Abstract

Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.

Entities:  

Keywords:  DNA damage; Jab1/CSN5; genomic instability; therapeutic approach; tumorigenesis

Mesh：

Substances：

Year:  2014        PMID： 24495954      PMCID： PMC3974825          DOI： 10.4161/cbt.27823

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  87 in total

1.  The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

Authors:  Eric S Fischer; Andrea Scrima; Kerstin Böhm; Syota Matsumoto; Gondichatnahalli M Lingaraju; Mahamadou Faty; Takeshi Yasuda; Simone Cavadini; Mitsuo Wakasugi; Fumio Hanaoka; Shigenori Iwai; Heinz Gut; Kaoru Sugasawa; Nicolas H Thomä
Journal:  Cell       Date:  2011-11-23       Impact factor: 41.582

2.  Ten genes for inherited breast cancer.

Authors:  Tom Walsh; Mary-Claire King
Journal:  Cancer Cell       Date:  2007-02       Impact factor: 31.743

3.  Targeted radiosensitization of cells expressing truncated DNA polymerase {beta}.

Authors:  Sari Neijenhuis; Manon Verwijs-Janssen; Lenie J van den Broek; Adrian C Begg; Conchita Vens
Journal:  Cancer Res       Date:  2010-10-26       Impact factor: 12.701

Review 4.  DNA damage, aging, and cancer.

Authors:  Jan H J Hoeijmakers
Journal:  N Engl J Med       Date:  2009-10-08       Impact factor: 91.245

5.  JAB1 is essential for B cell development and germinal center formation and inversely regulates Fas ligand and Bcl6 expression.

Authors:  Selina Sitte; Joachim Gläsner; Julia Jellusova; Florian Weisel; Martina Panattoni; Ruggero Pardi; André Gessner
Journal:  J Immunol       Date:  2012-02-10       Impact factor: 5.422

Review 6.  The COP9 signalosome.

Authors:  Ning Wei; Xing Wang Deng
Journal:  Annu Rev Cell Dev Biol       Date:  2003       Impact factor: 13.827

Review 7.  Platinum resistance: the role of DNA repair pathways.

Authors:  Lainie P Martin; Thomas C Hamilton; Russell J Schilder
Journal:  Clin Cancer Res       Date:  2008-03-01       Impact factor: 12.531

8.  Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations.

Authors:  S F Kwok; R Solano; T Tsuge; D A Chamovitz; J R Ecker; M Matsui; X W Deng
Journal:  Plant Cell       Date:  1998-11       Impact factor: 11.277

9.  Cytoplasmic localization of Jab1 and p27 Kip1 might be associated with invasiveness of papillary thyroid carcinoma.

Authors:  Jihyun Ahn; Soon Auck Hong; Seung-Eun Lee; Jaetaek Kim; Yeon Sahng Oh; Sung Jun Park; Yun Jae Chung
Journal:  Endocr J       Date:  2009-05-20       Impact factor: 2.349

10.  CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint.

Authors:  Sergey Doronkin; Inna Djagaeva; Steven K Beckendorf
Journal:  Development       Date:  2002-11       Impact factor: 6.868
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  28 in total

1.  Reverse correlation of Jab1 and Smad4 in PANC-1 cells involved in the pathogenesis of pancreatic cancer.

Authors:  Jun Li; Zhuoyu Gu; Siyuan Li; Zhiwei Xiao; Kan Sun
Journal:  Int J Clin Exp Pathol       Date:  2015-08-01

2.  CSN5 silencing inhibits invasion and arrests cell cycle progression in human colorectal cancer SW480 and LS174T cells in vitro.

Authors:  Gang Zhong; Huikai Li; Tao Shan; Nan Zhang
Journal:  Int J Clin Exp Pathol       Date:  2015-03-01

Review 3.  The emerging roles of Jab1/CSN5 in cancer.

Authors:  Lin Wang; Jun-Nian Zheng; Dong-Sheng Pei
Journal:  Med Oncol       Date:  2016-07-13       Impact factor: 3.064

4.  Jab1/Csn5-Thioredoxin Signaling in Relapsed Acute Monocytic Leukemia under Oxidative Stress.

Authors:  Fuling Zhou; Yunbao Pan; Yongchang Wei; Ronghua Zhang; Gaigai Bai; Qiuju Shen; Shan Meng; Xiao-Feng Le; Michael Andreeff; Francois X Claret
Journal:  Clin Cancer Res       Date:  2017-03-07       Impact factor: 12.531

5.  Jab1 promotes glioma cell proliferation by regulating Siah1/β-catenin pathway.

Authors:  Yufu Zhu; Zhichao Qiu; Xiang Zhang; Fengyuan Qian; Bin Wang; Lei Wang; Hengliang Shi; Rutong Yu
Journal:  J Neurooncol       Date:  2016-09-17       Impact factor: 4.130

6.  Over-expression of 5-HT6 Receptor and Activated Jab-1/p-c-Jun Play Important Roles in Pilocarpine-Induced Seizures and Learning-Memory Impairment.

Authors:  Changyun Liu; Yuxing Wen; Huapin Huang; Wanhui Lin; Mingzhu Huang; Rong Lin; Ying Ma
Journal:  J Mol Neurosci       Date:  2019-01-29       Impact factor: 3.444

Review 7.  Role of macrophage migration inhibitory factor in age-related lung disease.

Authors:  Maor Sauler; Richard Bucala; Patty J Lee
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-05-08       Impact factor: 5.464

8.  Macrophage-derived CCL5 facilitates immune escape of colorectal cancer cells via the p65/STAT3-CSN5-PD-L1 pathway.

Authors:  Chao Liu; Zhaoying Yao; Jianing Wang; Wen Zhang; Yan Yang; Yan Zhang; Xinliang Qu; Yubing Zhu; Jianjun Zou; Sishi Peng; Yan Zhao; Shuli Zhao; Bangshun He; Qiongyu Mi; Xiuting Liu; Xu Zhang; Qianming Du
Journal:  Cell Death Differ       Date:  2019-12-04       Impact factor: 15.828

9.  COP9 signalosome subunit CSN5, but not CSN6, is upregulated in lung adenocarcinoma and predicts poor prognosis.

Authors:  Dakai Xiao; Shengli Yang; Liyan Huang; Huiming He; Hui Pan; Jianxing He
Journal:  J Thorac Dis       Date:  2018-03       Impact factor: 2.895

Review 10.  Jab1/Cops5: a promising target for cancer diagnosis and therapy.

Authors:  Chunjue Yuan; Dong Wang; Guohong Liu; Yunbao Pan
Journal:  Int J Clin Oncol       Date:  2021-05-21       Impact factor: 3.402
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