Pierre-Yves Courand1, Hugues Milon2, Giampiero Bricca3, Fouad Khettab2, Pierre Lantelme4. 1. Cardiology Department, European Society of Hypertension Excellence center, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, F-69004 Lyon, France; Génomique Fonctionnelle de l'Hypertension artérielle, EA 4173, Université Claude Bernard Lyon1, F-69100 Villeurbanne, France; Hôpital Nord-Ouest, F-69400 Villefranche sur Saône, France. Electronic address: pycourand@hotmail.com. 2. Cardiology Department, European Society of Hypertension Excellence center, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, F-69004 Lyon, France. 3. Génomique Fonctionnelle de l'Hypertension artérielle, EA 4173, Université Claude Bernard Lyon1, F-69100 Villeurbanne, France; Hôpital Nord-Ouest, F-69400 Villefranche sur Saône, France. 4. Cardiology Department, European Society of Hypertension Excellence center, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, F-69004 Lyon, France; Génomique Fonctionnelle de l'Hypertension artérielle, EA 4173, Université Claude Bernard Lyon1, F-69100 Villeurbanne, France; Hôpital Nord-Ouest, F-69400 Villefranche sur Saône, France.
Abstract
OBJECTIVES: Our study aimed at determining the interaction between the prognostic value of diastolic blood pressure (DBP) and aortic atherosclerosis (ATS). BACKGROUND: With aging, equal systolic blood pressures (SBPs) become associated with low DBPs; i.e., high pulse pressures (PPs) become associated with a high risk of cardiovascular death. This association is usually ascribed to aortic stiffening with age but the precise impact of low DBP per se is yet uncertain. METHODS: 938 hypertensive patients recruited in the seventies had an aortic ATS score at pretreatment aortography. All-cause and cardiovascular deaths were assessed 20 years later. The prognostic values of DBP and SBP were assessed by a multivariate Cox regression model and their interactions with ATS examined. RESULTS: In the presence of ATS, an increase of 10 mmHg in DBP was associated with a protective effect: hazard ratios 0.84 [0.72-0.99] for cardiovascular death and 0.88 [0.78-1.00] for all-cause death. However, in the absence of ATS, DBP had no prognostic value: hazard ratios 1.05 [0.89-1.23] for cardiovascular death and 0.99 [0.88-1.11] for all-cause death (p for interaction: 0.061 and 0.087, respectively). No interaction was found between SBP and ATS (p for interaction > 0.40). CONCLUSIONS: The prognostic values of DBP and aortic atheroma are not superimposable; yet, they are tightly connected: a low DBP is disadvantageous only in the presence of a pathologic aorta. Aortic atherosclerosis may explain, at least partly, in some high risk populations, the J-shape of the already reported DBP-outcome relationship.
OBJECTIVES: Our study aimed at determining the interaction between the prognostic value of diastolic blood pressure (DBP) and aortic atherosclerosis (ATS). BACKGROUND: With aging, equal systolic blood pressures (SBPs) become associated with low DBPs; i.e., high pulse pressures (PPs) become associated with a high risk of cardiovascular death. This association is usually ascribed to aortic stiffening with age but the precise impact of low DBP per se is yet uncertain. METHODS: 938 hypertensivepatients recruited in the seventies had an aortic ATS score at pretreatment aortography. All-cause and cardiovascular deaths were assessed 20 years later. The prognostic values of DBP and SBP were assessed by a multivariate Cox regression model and their interactions with ATS examined. RESULTS: In the presence of ATS, an increase of 10 mmHg in DBP was associated with a protective effect: hazard ratios 0.84 [0.72-0.99] for cardiovascular death and 0.88 [0.78-1.00] for all-cause death. However, in the absence of ATS, DBP had no prognostic value: hazard ratios 1.05 [0.89-1.23] for cardiovascular death and 0.99 [0.88-1.11] for all-cause death (p for interaction: 0.061 and 0.087, respectively). No interaction was found between SBP and ATS (p for interaction > 0.40). CONCLUSIONS: The prognostic values of DBP and aortic atheroma are not superimposable; yet, they are tightly connected: a low DBP is disadvantageous only in the presence of a pathologic aorta. Aortic atherosclerosis may explain, at least partly, in some high risk populations, the J-shape of the already reported DBP-outcome relationship.
Authors: Pierre-Yves Courand; Helena Pereira; Costantino Del Giudice; Philippe Gosse; Matthieu Monge; Guillaume Bobrie; Pascal Delsart; Claire Mounier-Vehier; Pierre Lantelme; Thierry Denolle; Caroline Dourmap; Jean Michel Halimi; Xavier Girerd; Patrick Rossignol; Faiez Zannad; Olivier Ormezzano; Bernard Vaisse; Daniel Herpin; Jean Ribstein; Beatrice Bouhanick; Jean-Jacques Mourad; Emile Ferrari; Gilles Chatellier; Marc Sapoval; Arshid Azarine; Michel Azizi Journal: J Am Heart Assoc Date: 2017-10-10 Impact factor: 5.501