Zhendong Liu1, Yingxin Zhao2, Fang Wei3, Lin Ye4, Fanghong Lu2, Hua Zhang2, Yutao Diao2, Hongbin Song2, Zaiwen Qi2. 1. Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, No. 18877, Jingshi Road, Jinan, Shandong 250062, China. Electronic address: zhendongliu876@126.com. 2. Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, No. 18877, Jingshi Road, Jinan, Shandong 250062, China. 3. Department of Cardiology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, China. 4. Department of Cardiology, Shandong Provencial Hospital, Jinan, Shandong 250021, China.
Abstract
OBJECTIVES: To explore synergistic effect between angiotensin II receptor blockers (ARBs) and statins on Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis. METHODS: This study was a 2 × 2 factorial randomized, prospective, double-blind, placebo-controlled trial. One hundred and fifty nine hypertensive patients with carotid atherosclerosis were randomized to the administration of control group, telmisartan group, rosuvastatin group, and combination group (telmisartan plus rosuvastatin) base on hydrochlorothiazide treatment. Carotid ultrasonography, parameters of Th17/Treg functional axis, interleukin (IL)-1β, IL-2, interferon (IFN)-γ, hypersensitive C-reactive protein (hsCRP), monocyte chemotactic protein (MCP)-1 were evaluated. RESULTS:Blood pressure level markedly reduced in four groups. There was significantly synergistic effect of combination of telmisartan with rosuvastatin on reducing carotid imtima-media thickness (IMT), Th17 cells frequency, IL-17, IL-6, IL-23, tumor necrosis factor (TNF)-α, expression of retinoic acid receptor-related orphan receptor (ROR)γt mRNA, Th17/Treg ratio, IL-1β, IL-2, IFN-γ, hsCRP, and MCP-1, and increasing Treg cells frequency, IL-10, transforming growth factor(TGF)-β1, and expression of forkhead/winged helix transcription factor (Foxp3) mRNA (all P<0.05). Change rate of IMT statistical positively related to descent rates of Th17 cells frequency, IL-17, IL-6, IL-23, TNF-α, expression of RORγt mRNA, Th17/Treg ratio, IL-1β, IL-2, IFN-γ, hsCRP, and MCP-1, and negatively related to increased rates of Treg frequency, IL-10, TGF-β1, and expression of Foxp3 mRNA, respectively (all P<0.05). CONCLUSION: There is a synergistic effect of combination of telmisartan with rosuvastatin on ameliorating Th17/Treg functional imbalance in hypertensive patients with carotid atherosclerosis.
RCT Entities:
OBJECTIVES: To explore synergistic effect between angiotensin II receptor blockers (ARBs) and statins on Th17/Treg functional imbalance in hypertensivepatients with carotid atherosclerosis. METHODS: This study was a 2 × 2 factorial randomized, prospective, double-blind, placebo-controlled trial. One hundred and fifty nine hypertensivepatients with carotid atherosclerosis were randomized to the administration of control group, telmisartan group, rosuvastatin group, and combination group (telmisartan plus rosuvastatin) base on hydrochlorothiazide treatment. Carotid ultrasonography, parameters of Th17/Treg functional axis, interleukin (IL)-1β, IL-2, interferon (IFN)-γ, hypersensitiveC-reactive protein (hsCRP), monocyte chemotactic protein (MCP)-1 were evaluated. RESULTS: Blood pressure level markedly reduced in four groups. There was significantly synergistic effect of combination of telmisartan with rosuvastatin on reducing carotid imtima-media thickness (IMT), Th17 cells frequency, IL-17, IL-6, IL-23, tumor necrosis factor (TNF)-α, expression of retinoic acid receptor-related orphan receptor (ROR)γt mRNA, Th17/Treg ratio, IL-1β, IL-2, IFN-γ, hsCRP, and MCP-1, and increasing Treg cells frequency, IL-10, transforming growth factor(TGF)-β1, and expression of forkhead/winged helix transcription factor (Foxp3) mRNA (all P<0.05). Change rate of IMT statistical positively related to descent rates of Th17 cells frequency, IL-17, IL-6, IL-23, TNF-α, expression of RORγt mRNA, Th17/Treg ratio, IL-1β, IL-2, IFN-γ, hsCRP, and MCP-1, and negatively related to increased rates of Treg frequency, IL-10, TGF-β1, and expression of Foxp3 mRNA, respectively (all P<0.05). CONCLUSION: There is a synergistic effect of combination of telmisartan with rosuvastatin on ameliorating Th17/Treg functional imbalance in hypertensivepatients with carotid atherosclerosis.
Authors: Madhu V Singh; Michael Z Cicha; Santosh Kumar; David K Meyerholz; Kaikobad Irani; Mark W Chapleau; François M Abboud Journal: J Allergy Clin Immunol Date: 2017-01-16 Impact factor: 10.793
Authors: Miao Hu; Hon-Kit Lee; Kenneth K W To; Benny S P Fok; Siu-Kwan Wo; Chung-Shun Ho; Chun-Kwok Wong; Zhong Zuo; Thomas Y K Chan; Juliana C N Chan; Brian Tomlinson Journal: Eur J Clin Pharmacol Date: 2016-09-20 Impact factor: 2.953
Authors: Katalin Réka Czuriga-Kovács; Csilla Cecília Szekeres; Zoltán Bajkó; Krisztina Csapó; László Oláh; Mária Tünde Magyar; Sándor Molnár; Dániel Czuriga; László Kardos; Andrea Bojtor Burainé; Dániel Bereczki; Pál Soltész; László Csiba Journal: J Clin Hypertens (Greenwich) Date: 2019-04-13 Impact factor: 3.738
Authors: José Francisco Zambrano-Zaragoza; Enrique Jhonatan Romo-Martínez; Ma de Jesús Durán-Avelar; Noemí García-Magallanes; Norberto Vibanco-Pérez Journal: Int J Inflam Date: 2014-08-03