Jie Zhang1, Yan Zeng, Jun Zheng, Jiang Xu2. 1. Department of Stomatology, The First Affiliated Hospital, Medical College of Shihezi University, Shihezi Xinjiang Uygur Autonomous Region 832000, China. 2. Email:1437759520@qq.com.
Abstract
OBJECTIVE: To examine Prion protein(PrP) expression and its clinical significance in oral mucosa, oral leukoplakia, oral squamous cell carcinoma(OSCC) and its subgroups. METHODS: Expression of PrP in OSCC, oral leukoplakia and mucosa specimen was detected by immunohistochemistry. The association between the expression and gender, TNM clinical stages, pathological grades was evaluated. RESULTS: The positive expression rate of PrP in normal, oral leukoplakia and OSCC tissues was 15% (3/20) , 42% (11/26) and 95% (80/84) , respectively. There was a significant difference between the expression of PrP in leukoplakia and in high, moderately and poorly differentiated OSCC(P < 0.05). The positive expression rate was increased with the declining of pathological differentiation (P < 0.05). There was no significant difference in PrP expression among lymph node metastasis and gender. PrP expression of stages I and II was up-regulated with the decreased differentiation (P < 0.05). There was no significant difference in PrP expression between stage III and IV (P > 0.05). Between stages I+II and III+IV in the overa II expression of PrP, there was a significant difference(P < 0.05). CONCLUSIONS: The high expression of PrP in OSCC and the progressive expression from leukoplakia to OSCC was closely related to the carcinogenesis of OSCC, pathologic stage and clinical TNM stage.
OBJECTIVE: To examine Prion protein(PrP) expression and its clinical significance in oral mucosa, oral leukoplakia, oral squamous cell carcinoma(OSCC) and its subgroups. METHODS: Expression of PrP in OSCC, oral leukoplakia and mucosa specimen was detected by immunohistochemistry. The association between the expression and gender, TNM clinical stages, pathological grades was evaluated. RESULTS: The positive expression rate of PrP in normal, oral leukoplakia and OSCC tissues was 15% (3/20) , 42% (11/26) and 95% (80/84) , respectively. There was a significant difference between the expression of PrP in leukoplakia and in high, moderately and poorly differentiated OSCC(P < 0.05). The positive expression rate was increased with the declining of pathological differentiation (P < 0.05). There was no significant difference in PrP expression among lymph node metastasis and gender. PrP expression of stages I and II was up-regulated with the decreased differentiation (P < 0.05). There was no significant difference in PrP expression between stage III and IV (P > 0.05). Between stages I+II and III+IV in the overa II expression of PrP, there was a significant difference(P < 0.05). CONCLUSIONS: The high expression of PrP in OSCC and the progressive expression from leukoplakia to OSCC was closely related to the carcinogenesis of OSCC, pathologic stage and clinical TNM stage.