| Literature DB >> 24495078 |
Jixing Peng1, Xiaomin Zhang, Lin Du, Wei Wang, Tianjiao Zhu, Qianqun Gu, Dehai Li.
Abstract
Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against influenza virus A (H1N1), with IC50 values of 85 and 113 μ M, respectively.Entities:
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Year: 2014 PMID： 24495078 DOI： 10.1021/np400977e
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050