Vincent Wai-Sun Wong1, Grace Lai-Hung Wong1, David Ka-Wai Yeung2, Jill M Abrigo3, Alice Pik-Shan Kong4, Ruth Suk-Mei Chan5, Angel Mei-Ling Chim1, Jiayun Shen1, Chung-Shun Ho6, Jean Woo5, Winnie Chiu-Wing Chu7, Henry Lik-Yuen Chan1. 1. 1] Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China [2] Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. 2. Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China. 3. Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China. 4. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. 5. 1] Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China [2] Centre for Nutritional Studies, The Chinese University of Hong Kong, Hong Kong, China. 6. Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China. 7. 1] Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China [2] Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China.
Abstract
OBJECTIVES: Nonalcoholic fatty liver disease is the most common chronic liver disease. Fatty pancreas has also been described but is difficult to assess. It is now possible to measure pancreatic and liver fat accurately with magnetic resonance imaging (MRI). We aimed to define the normal range of pancreatic fat and identify factors associated with fatty pancreas. In addition, the effect of fatty liver and fatty pancreas on insulin resistance (IR) and pancreatic β-cell function was studied. METHODS: Fat-water MRI and proton-magnetic resonance spectroscopy were performed on 685 healthy volunteers from the general population to measure pancreatic and liver fat, respectively. On the basis of fasting plasma glucose and insulin levels, the IR and β-cell function were assessed using the homeostasis model assessment (HOMA). RESULTS: Among subjects without significant alcohol consumption or any component of metabolic syndrome, 90% had pancreatic fat between 1.8 and 10.4%. Using the upper limit of normal of 10.4%, 110 (16.1%; 95% confidence interval 13.3-18.8%) subjects had fatty pancreas. On multivariable analysis, high serum ferritin, central obesity, and hypertriglyceridemia were independent factors associated with fatty pancreas. Subjects with both fatty pancreas and fatty liver had higher HOMA-IR than did those with either condition alone. Fatty pancreas was not associated with HOMA-β after adjusting for liver fat and body mass index. CONCLUSIONS: In all, 16.1% of this community cohort of adult Hong Kong Chinese volunteers had a fatty pancreas by our definition. Central obesity, hypertriglyceridemia, and hyperferritinemia are associated with fatty pancreas. Individuals with fatty pancreas have increased IR.
OBJECTIVES:Nonalcoholic fatty liver disease is the most common chronic liver disease. Fatty pancreas has also been described but is difficult to assess. It is now possible to measure pancreatic and liver fat accurately with magnetic resonance imaging (MRI). We aimed to define the normal range of pancreatic fat and identify factors associated with fatty pancreas. In addition, the effect of fatty liver and fatty pancreas on insulin resistance (IR) and pancreatic β-cell function was studied. METHODS: Fat-water MRI and proton-magnetic resonance spectroscopy were performed on 685 healthy volunteers from the general population to measure pancreatic and liver fat, respectively. On the basis of fasting plasma glucose and insulin levels, the IR and β-cell function were assessed using the homeostasis model assessment (HOMA). RESULTS: Among subjects without significant alcohol consumption or any component of metabolic syndrome, 90% had pancreatic fat between 1.8 and 10.4%. Using the upper limit of normal of 10.4%, 110 (16.1%; 95% confidence interval 13.3-18.8%) subjects had fatty pancreas. On multivariable analysis, high serum ferritin, central obesity, and hypertriglyceridemia were independent factors associated with fatty pancreas. Subjects with both fatty pancreas and fatty liver had higher HOMA-IR than did those with either condition alone. Fatty pancreas was not associated with HOMA-β after adjusting for liver fat and body mass index. CONCLUSIONS: In all, 16.1% of this community cohort of adult Hong Kong Chinese volunteers had a fatty pancreas by our definition. Central obesity, hypertriglyceridemia, and hyperferritinemia are associated with fatty pancreas. Individuals with fatty pancreas have increased IR.
Authors: Steve C N Hui; Simon K H Wong; Qiyong Ai; David K W Yeung; Enders K W Ng; Winnie C W Chu Journal: Eur Radiol Date: 2018-07-30 Impact factor: 5.315
Authors: Takeshi Yokoo; Suraj D Serai; Ali Pirasteh; Mustafa R Bashir; Gavin Hamilton; Diego Hernando; Houchun H Hu; Holger Hetterich; Jens-Peter Kühn; Guido M Kukuk; Rohit Loomba; Michael S Middleton; Nancy A Obuchowski; Ji Soo Song; An Tang; Xinhuai Wu; Scott B Reeder; Claude B Sirlin Journal: Radiology Date: 2017-09-11 Impact factor: 11.105