| Literature DB >> 24492008 |
Yolanda Stypula-Cyrus1, Nikhil N Mutyal2, Mart Dela Cruz3, Dhananjay P Kunte4, Andrew J Radosevich2, Ramesh Wali3, Hemant K Roy5, Vadim Backman2.
Abstract
End-binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression is unknown. Therefore, we analyzed EB1/APC expression at the earliest stages of colorectal carcinogenesis and in the uninvolved mucosa ("field effect") of human and animal tissue. We also performed siRNA-knockdown in colon cancer cell lines. EB1 is up-regulated in early and field carcinogenesis in the colon, and the cellular/nano-architectural effect of EB1 knockdown depended on the genetic context. Thus, dysregulation of EB1 is an important early event in colon carcinogenesis.Entities:
Keywords: Adenomatous polyposis coli; Colon cancer; End-binding protein 1; Field carcinogenesis; Sub-diffractional structure
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Year: 2014 PMID： 24492008 PMCID： PMC4103177 DOI： 10.1016/j.febslet.2014.01.046
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124