Dorothy J Yamamoto1, Jeremy Reynolds2, Theodore Krmpotich1, Marie T Banich3, Laetitia Thompson4, Jody Tanabe5. 1. Department of Radiology, University of Colorado Denver, 12700 E. 19th Avenue, Mail Stop C278, Aurora, CO 80045, USA. 2. Department of Psychology, University of Denver, 2155 S. Race Street, Denver, CO 80208, USA. 3. Department of Psychiatry, University of Colorado Denver, 13001 E. 17th Place, Mail Stop F546, Aurora, CO 80045, USA; Institute of Cognitive Science, University of Colorado Boulder, D420 Muenziger Building, Campus Box 345, Boulder, CO 80309, USA. 4. Department of Psychiatry, University of Colorado Denver, 13001 E. 17th Place, Mail Stop F546, Aurora, CO 80045, USA. 5. Department of Radiology, University of Colorado Denver, 12700 E. 19th Avenue, Mail Stop C278, Aurora, CO 80045, USA; Department of Psychiatry, University of Colorado Denver, 13001 E. 17th Place, Mail Stop F546, Aurora, CO 80045, USA. Electronic address: jody.tanabe@ucdenver.edu.
Abstract
BACKGROUND: Substance dependence is associated with impaired decision-making and altered fronto-striatal-limbic activity. Both greater and lesser brain activity have been reported in drug users compared to controls during decision-making. Inconsistent results might be explained by group differences in the temporal profile of the functional magnetic resonance imaging (fMRI) response. While most previous studies model a canonical hemodynamic response, a finite impulse response (FIR) model measures fMRI signal at discrete time points without assuming a temporal profile. We compared brain activity during decision-making and feedback in substance users and controls using two models: a canonical hemodynamic response function (HRF) and a FIR model. METHODS: 37 substance-dependent individuals (SDI) and 43 controls performed event-related decision-making during fMRI scanning. Brain activity was compared across group using canonical HRF and FIR models. RESULTS: Compared to controls, SDI were impaired at decision-making. The canonical HRF model showed that SDI had significantly greater fronto-striatal-limbic activity during decisions and less activity during feedback than controls. The FIR model confirmed greater activity in SDI during decisions. However, lower activity in SDI during feedback corresponded to a lower post-stimulus undershoot of the hemodynamic response. CONCLUSIONS: Greater activity in fronto-striatal-limbic pathways in SDI compared to controls is consistent with prior work, further supporting the hypothesis that abnormalities in these circuits underlie impaired decision-making. We demonstrate for the first time using FIR analysis that lower activity during feedback may simply reflect the tail end of the hemodynamic response to decision, the post-stimulus undershoot, rather than an actual difference in feedback response.
BACKGROUND: Substance dependence is associated with impaired decision-making and altered fronto-striatal-limbic activity. Both greater and lesser brain activity have been reported in drug users compared to controls during decision-making. Inconsistent results might be explained by group differences in the temporal profile of the functional magnetic resonance imaging (fMRI) response. While most previous studies model a canonical hemodynamic response, a finite impulse response (FIR) model measures fMRI signal at discrete time points without assuming a temporal profile. We compared brain activity during decision-making and feedback in substance users and controls using two models: a canonical hemodynamic response function (HRF) and a FIR model. METHODS: 37 substance-dependent individuals (SDI) and 43 controls performed event-related decision-making during fMRI scanning. Brain activity was compared across group using canonical HRF and FIR models. RESULTS: Compared to controls, SDI were impaired at decision-making. The canonical HRF model showed that SDI had significantly greater fronto-striatal-limbic activity during decisions and less activity during feedback than controls. The FIR model confirmed greater activity in SDI during decisions. However, lower activity in SDI during feedback corresponded to a lower post-stimulus undershoot of the hemodynamic response. CONCLUSIONS: Greater activity in fronto-striatal-limbic pathways in SDI compared to controls is consistent with prior work, further supporting the hypothesis that abnormalities in these circuits underlie impaired decision-making. We demonstrate for the first time using FIR analysis that lower activity during feedback may simply reflect the tail end of the hemodynamic response to decision, the post-stimulus undershoot, rather than an actual difference in feedback response.
Authors: Karen J Mullinger; Stephen D Mayhew; Andrew P Bagshaw; Richard Bowtell; Susan T Francis Journal: Proc Natl Acad Sci U S A Date: 2013-07-29 Impact factor: 11.205
Authors: Jun Hua; Robert D Stevens; Alan J Huang; James J Pekar; Peter C M van Zijl Journal: J Cereb Blood Flow Metab Date: 2011-04-06 Impact factor: 6.200
Authors: Nora D Volkow; Gene-Jack Wang; Frank Telang; Joanna S Fowler; Jean Logan; Anna-Rose Childress; Millard Jayne; Yeming Ma; Christopher Wong Journal: J Neurosci Date: 2006-06-14 Impact factor: 6.167
Authors: Dorothy J Yamamoto; Choong-Wan Woo; Tor D Wager; Michael F Regner; Jody Tanabe Journal: Drug Alcohol Depend Date: 2015-02-16 Impact factor: 4.492
Authors: Dorothy J Yamamoto; Marie T Banich; Michael F Regner; Joseph T Sakai; Jody Tanabe Journal: Drug Alcohol Depend Date: 2017-09-14 Impact factor: 4.492