Literature DB >> 2449138

Occurrence of substance P, vasoactive intestinal peptide, and calcitonin gene-related peptide in dermographism and cold urticaria.

J Wallengren1, H Möller, R Ekman.   

Abstract

Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides, and VIP in particular, was higher in the urticaria patients than in control subjects. CGRP levels were not increased. SP and VIP in blood samples from veins draining challenged skin areas were below the detection limit. It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of the skin to trauma and temperature changes in patients with physical urticaria.

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Year:  1987        PMID： 2449138     DOI： 10.1007/bf00413281

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  20 in total

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Authors:  J Wallengren; R Håkanson
Journal:  Eur J Pharmacol       Date:  1987-11-10       Impact factor: 4.432

3.  Suction blister device for separation of viable epidermis from dermis.

Authors:  U Kiistala
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5.  Experimental studies on dermographism.

Authors:  R K Winkelmann; C M Wilhelmj; F A Horner
Journal:  Arch Dermatol       Date:  1965-10

6.  Peptidergic (neurotensin, VIP, substance P) nerve fibres in the skin. Immunohistochemical evidence of an involvement of neuropeptides in nociception, pruritus and inflammation.

Authors:  W Hartschuh; E Weihe; M Reinecke
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7.  Assessment of tissue fluid histamine levels in patients with urticaria.

Authors:  A P Kaplan; Z Horáková; S I Katz
Journal:  J Allergy Clin Immunol       Date:  1978-06       Impact factor: 10.793

8.  Cold urticaria. Dissociation of cold-evoked histamine release and urticara following cold challenge.

Authors:  T M Keahey; M W Greaves
Journal:  Arch Dermatol       Date:  1980-02

9.  Some effects of calcitonin gene-related peptide in human skin and on histamine release.

Authors:  W Piotrowski; J C Foreman
Journal:  Br J Dermatol       Date:  1986-01       Impact factor: 9.302

10.  Neurogenic inflammation in skin blisters.

Authors:  R D Helme; D M White; P V Andrews
Journal:  Exp Brain Res       Date:  1985       Impact factor: 1.972
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Review 6.  Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?

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