| Literature DB >> 24491352 |
Alessandra Hubner de Souza1, Aírton Martins da Costa Lopes2, Célio J Castro2, Elizete Maria Rita Pereira3, Caroline Peres Klein4, Claudio Antonio da Silva2, Juliana Figueira da Silva3, Juliano Ferreira5, Marcus Vinicius Gomez6.
Abstract
This study investigated the effects of Phα1β, pregabalin and diclofenac using an animal model of fibromyalgia (FM). Repeated administration of reserpine (0.25 mg/kg sc) once daily for three consecutive days significantly decreased thermal hyperalgesia, mechanical allodynia, and dopamine and serotonin content in the brain on the 4th day. Phα1β and pregabalin treatment completely reverted the mechanical allodynia and thermal hyperalgesia induced by reserpine treatment on the 4th day, but diclofenac was ineffective. Reserpine treatment significantly increased the immobility time in the forced swim test, which is indicative of depression in the animals. Phα1β, but not pregabalin, reduced the immobility time (56%), suggesting that Phα1β may control persistent pathological pain in FM.Entities:
Keywords: Diclofenac; Fibromyalgia model; Phα1β; Pregabalin; Treatment
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Year: 2014 PMID： 24491352 DOI： 10.1016/j.toxicon.2014.01.015
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033