Literature DB >> 24490125

Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols.

Laura Raccosta1, Raffaella Fontana1, Catia Traversari2, Vincenzo Russo1.   

Abstract

By binding to the liver X receptor (LXR), oxysterols inhibit the expression of chemokine (C-C motif) receptor 7 (CCR7), hence impairing the migration of dendritic cells to secondary lymphoid organs and inhibiting antitumor immune responses. We have recently identified a new tumor-supporting activity of oxysterols, which recruit neutrophils within tumor microenvironment by a chemokine (C-X-C motif) receptor 2 (CXCR2)-dependent, LXR-independent mechanism.

Entities:  

Keywords:  CXCR2; immune evasion; microenvironment; oxysterols; tumor-infiltrating neutrophils

Year:  2013        PMID： 24490125      PMCID： PMC3897566          DOI： 10.4161/onci.26469

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

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Authors:  Laurence Zitvogel; Antoine Tesniere; Guido Kroemer
Journal:  Nat Rev Immunol       Date:  2006-09-15       Impact factor: 53.106

Review 2.  Integration of metabolism and inflammation by lipid-activated nuclear receptors.

Authors:  Steven J Bensinger; Peter Tontonoz
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Review 3.  Neutrophils in the activation and regulation of innate and adaptive immunity.

Authors:  Alberto Mantovani; Marco A Cassatella; Claudio Costantini; Sébastien Jaillon
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Review 4.  Sterols and oxysterols in immune cell function.

Authors:  Nathanael J Spann; Christopher K Glass
Journal:  Nat Immunol       Date:  2013-09       Impact factor: 25.606

Review 5.  Natural innate and adaptive immunity to cancer.

Authors:  Matthew D Vesely; Michael H Kershaw; Robert D Schreiber; Mark J Smyth
Journal:  Annu Rev Immunol       Date:  2011       Impact factor: 28.527

Review 6.  The role of orphan nuclear receptors in the regulation of cholesterol homeostasis.

Authors:  J J Repa; D J Mangelsdorf
Journal:  Annu Rev Cell Dev Biol       Date:  2000       Impact factor: 13.827

Review 7.  From tumor cell metabolism to tumor immune escape.

Authors:  Martin Villalba; Moeez G Rathore; Nuria Lopez-Royuela; Ewelina Krzywinska; Johan Garaude; Nerea Allende-Vega
Journal:  Int J Biochem Cell Biol       Date:  2012-05-05       Impact factor: 5.085

8.  Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses.

Authors:  Eduardo J Villablanca; Laura Raccosta; Dan Zhou; Raffaella Fontana; Daniela Maggioni; Aurora Negro; Francesca Sanvito; Maurilio Ponzoni; Barbara Valentinis; Marco Bregni; Alessandro Prinetti; Knut R Steffensen; Sandro Sonnino; Jan-Ake Gustafsson; Claudio Doglioni; Claudio Bordignon; Catia Traversari; Vincenzo Russo
Journal:  Nat Med       Date:  2009-12-27       Impact factor: 53.440

Review 9.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

10.  The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.

Authors:  Laura Raccosta; Raffaella Fontana; Daniela Maggioni; Claudia Lanterna; Eduardo J Villablanca; Aida Paniccia; Andrea Musumeci; Elena Chiricozzi; Maria Letizia Trincavelli; Simona Daniele; Claudia Martini; Jan-Ake Gustafsson; Claudio Doglioni; Safiyè Gonzalvo Feo; Andrea Leiva; Maria Grazia Ciampa; Laura Mauri; Cristina Sensi; Alessandro Prinetti; Ivano Eberini; J Rodrigo Mora; Claudio Bordignon; Knut R Steffensen; Sandro Sonnino; Silvano Sozzani; Catia Traversari; Vincenzo Russo
Journal:  J Exp Med       Date:  2013-07-29       Impact factor: 14.307
  10 in total
  2 in total

1.  Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.

Authors:  Rebecca Swan; Abdo Alnabulsi; Beatriz Cash; Ayham Alnabulsi; Graeme I Murray
Journal:  Oncotarget       Date:  2016-07-19

Review 2.  Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses.

Authors:  Maximilian Rentschler; Heidi Braumüller; Priscilla S Briquez; Thomas Wieder
Journal:  Cancers (Basel)       Date:  2022-03-08       Impact factor: 6.639
  2 in total

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