| Literature DB >> 24489463 |
K Grimmer1, S Milanese1, K Beaton1, A Atlas1.
Abstract
INTRODUCTION: The Hospital Admission Risk Profile (HARP) instrument is commonly used to assess risk of functional decline when older people are admitted to hospital. HARP has moderate diagnostic accuracy (65%) for downstream decreased scores in activities of daily living. This paper reports the diagnostic accuracy of HARP for downstream quality of life. It also tests whether adding other measures to HARP improves its diagnostic accuracy.Entities:
Keywords: HARP; functional decline; older people; quality of life
Mesh:
Year: 2014 PMID: 24489463 PMCID: PMC3904779 DOI: 10.2147/CIA.S56086
Source DB: PubMed Journal: Clin Interv Aging ISSN: 1176-9092 Impact factor: 4.458
Figure 1Age-sex classifications for participants.
Age classification means for physical and mental component quality of life scores at 1 and 3 months
| Age group | Number observations | Variable | Number | Mean | Standard deviation |
|---|---|---|---|---|---|
| 65–74 years | 68 | MCS_1 | 68 | 51.6 | 8.3 |
| PCS_1 | 68 | 44.4 | 11.9 | ||
| MCS_3 | 68 | 51.9 | 8.5 | ||
| PCS_3 | 68 | 45.9 | 12.2 | ||
| 75–84 years | 57 | MCS_1 | 57 | 52.2 | 8.2 |
| PCS_1 | 57 | 44.3 | 9.3 | ||
| MCS_3 | 57 | 53.5 | 7.8 | ||
| PCS_3 | 57 | 40.5 | 10.1 | ||
| 85–94 years | 19 | MCS_1 | 19 | 56.5 | 5.3 |
| PCS_1 | 19 | 43.4 | 11.2 | ||
| MCS_3 | 19 | 54.5 | 6.5 | ||
| PCS_3 | 19 | 43.8 | 8.9 | ||
| 95+ years | 4 | MCS_1 | 4 | 37.5 | 11.0 |
| PCS_1 | 4 | 39.5 | 13.3 | ||
| MCS_3 | 4 | 53.7 | 3.9 | ||
| PCS_3 | 4 | 32.2 | 6.6 |
Notes: MCS_1 is the component quality of life score at 1 month post recruitment; MCS_3 is mental component quality of life score at 3 months post recruitment; PCS_1 is physical component quality of life score at 1 month post recruitment; PCS_3 is physical component quality of life score at 3 months post recruitment.
Abbreviations: MCS, mental component score; PCS, physical component score.
Association between HARP and quality of life components (MCS and PCS)
| OR | 95% CI | Sensitivity | Specificity | AUC | |
|---|---|---|---|---|---|
| Low MCS at 1 month (point in time) | 0.9 | 0.5–1.8 | 56.7% (44.7–68.2) | 44.6% (33.0–56.6) | 0.51 (0.42–0.59) |
| Low MCS at 3 months (point in time) | 1.2 | 0.6–2.2 | 44.8% (32.6–57.4) | 57.3% (45.9–68.2) | 0.51 (0.43–0.59) |
| Low or declining MCS scores over 2 months (change over time) | 1.3 | 0.4–2.4 | 56.0% (34.9–75.6) | 58.5% (49.3–67.3) | 0.57 (0.48–0.65) |
| Low PCS at 1 month (point in time) | 56.3% (43.3–68.6) | 65.5% (54.3–75.5) | 0.61 (0.52–0.69) | ||
| Low PCS at 3 months (point in time) | 57.2% (44.3–67.7) | 66.1% (54.8–74.5) | 0.62 (0.51–0.68) | ||
| Low or declining PCS scores over 2 months (change over time) | 56.3% (44.0–68.1) | 67.9% (56.4–78.1) | 0.62 (0.54–0.70) | ||
| Low or declining PCS and MCS scores over 2 months (change over time) | 1.6 | 0.8–3.4 | 53.8% (33.4–73.4) | 58.5% (49.3–67.3) | 0.56 (0.48–0.64) |
Note: The bold numbers indicate the significant associations.
Abbreviations: AUC, area under the curve; CI, confidence interval; HARP, Hospital Admission Risk Profile; MCS, mental component score; OR, odds ratio; PCS, physical component score.
Figure 2Receiver operator characteristic curve derived from HARP predicting consistently low or declining PCS over 2 months (1 and 3 months after HARP was calculated).
Abbreviations: HARP, Hospital Admission Risk Profile; PCS, physical component score.
Quality of life (as measured by SF12 component scores) and predictor variables of FD
| MCS 1 month
| MCS 3 months
| PCS 1 month
| PCS 3 months
| |||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Having a carer | 0.9 | 0.5–1.8 | ||||||
| Receiving community support | 0.9 | 0.4–1.9 | 1.2 | 0.6–2.2 | ||||
| Using a gait aid | 1.1 | 0.6–2.3 | ||||||
| Primary language not English | 1.0 | 0.4–2.3 | 1.0 | 0.4–2.3 | 0.7 | 0.3–1.7 | ||
| Living alone | 0.8 | 0.4–1.5 | 1.2 | 0.6–2.2 | 1.2 | 0.6–2.3 | 0.9 | 0.5–1.7 |
| SES 1–2 (low) | 1.0 | 1.0 | 1.0 | 1.0 | ||||
| SES 3–4 | 0.2 | 0.1–1.4 | 0.5 | 0.1–2.6 | 0.3 | 0.1–1.7 | 0.2 | 0.1–1.4 |
| SES 5–6 (moderate) | 0.5 | 0.2–2.9 | 0.6 | 0.2–2.2 | 0.9 | 0.2–3.5 | 0.5 | 0.1–1.9 |
| SES 7–8 | 0.5 | 0.1–1.8 | 0.6 | 0.1–2.2 | 0.9 | 0.2–3.5 | 0.5 | 0.1–1.9 |
| SES 9–10 (high) | 0.4 | 0.1–1.4 | 0.4 | 0.1–1.3 | 0.9 | 0.3–3.2 | 0.6 | 0.2–2.1 |
Note: The numbers in bold indicate the significant associations.
Abbreviations: CI, confidence interval; MCS, mental component score; OR, odds ratio; PCS, physical component score; SES, socioeconomic status; FD, functional decline; SF12, 12-item Short Form Health Survey.
Univariate associations between FD predictor variables
| HARP | Carer | Community support | Gait aid | English | Living alone | SES 3–4 moderately low | SES 5–6 moderate | SES 7–8 moderately high | SES 9–10 high | |
|---|---|---|---|---|---|---|---|---|---|---|
| HARP | 1 | 0.9 (0.4–2.0) | 0.4 (0.1–2.4) | 1.7 (0.4–6.6) | 1.3 (0.4–4.9) | 1.3 (0.4–4.5) | ||||
| Carer | 1 | 1.5 (0.6–4.0) | 1.9 (0.8–4.7) | 0.6 (0.2–1.7) | 0.9 (0.4–2.3) | 0.3 (0.1–3.7) | 0.4 (0.1–2.4) | 0.9 (0.2–4.1) | 0.5 (0.1–2.4) | |
| Community support | 1 | 2.1 (0.7–6.5) | 0.2 (0.1–2.4) | 0.6 (0.1–2.8) | 0.6 (0.1–2.6) | 0.8 (0.2–2.9) | ||||
| Gait aid | 1 | 1.4 (0.6–3.6) | 0.2 (0.1–2.4) | 1.3 (0.3–5.4) | 1.1 (0.3–4.5) | 1.0 (0.3–3.7) | ||||
| English | 1 | 1.2 (0.5–2.9) | 2.8 (0.5–16.0) | 1.7 (0.4–7.6) | 2.8 (0.6–11.9) | 2.4 (0.6–9.7) | ||||
| Living alone | 1 | 0.4 (0.1–4.8) | 0.4 (0.1–3.5) | 0.3 (0.1–2.8) | 0.3 (0.1–2.7) |
Note: The numbers in bold indicate the significant associations.
Abbreviations: FD, functional decline; HARP, Hospital Admission Risk Profile; SES, socioeconomic status.
Figure 3Three month trajectory of the likelihood of high PCS (from SF12 quality of life measure; ORs, 95% CIs), after being assessed with a moderate or high HARP score at baseline.
Abbreviations: CI, confidence interval; HARP, Hospital Admission Risk Profile; L, lower; OR, odds ratio; PCS, physical component score; U, upper; SF12, 12-item Short Form Health Survey.
Exploring differences in individuals with low MCS at 1 month who deteriorated or improved in PCS over 2 months (between 1 month and 3 months after HARP assessment)
| Deteriorating PCS
| Improving PCS
| |||||
|---|---|---|---|---|---|---|
| Baseline | 1 month | 3 months | Baseline | 1 month | 3 months | |
| English not primary language | 8/9 | 8/9 | ||||
| Use of gait aid | 4/9 | 5/9 | 5/9 | 1/9 | 1/9 | 1/9 |
| Fallers | 4/9 over past 12 months | 1/9 in past month | 1/9 in past 2 months | 4 over past 12 months | 0/9 in past month | 1/9 in past 2 months |
| Number of falls | 6 | 1 | 1 | 7 | 0 | 3 |
| Hospitalized participants | 1/9 over past 6 months | 2/9 in past month | 5/9 in past 2 months | 1/9 over past 6 months | 4/9 in past month | 5/9 in past 2 months |
| Number of hospitalizations | 1 | 3 | 14 | 2 | 5 | 9 |
| Current use of community services | 3/9 | 1/9 | 1/9 | 3/9 | 3/9 | 3/9 |
Abbreviations: HARP, Hospital Admission Risk Profile; MCS, mental component score; PCS, physical component score.