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Literature DB >> 24487640

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling.

Abstract

During bone resorption, abundant factors previously buried in the bone matrix are released into the bone marrow microenvironment, which results in recruitment and differentiation of bone marrow mesenchymal stem cells (MSCs) for subsequent bone formation, temporally and spatially coupling bone remodeling. Parathyroid hormone (PTH) orchestrates the signaling of many pathways that direct MSC fate. The spatiotemporal release and activation of matrix TGF-β during osteoclast bone resorption recruits MSCs to bone-resorptive sites. Dysregulation of TGF-β alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-β or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.

Entities: Disease Gene

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Year: 2014 PMID： 24487640 PMCID： PMC3904610 DOI： 10.1172/JCI70050

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

117 in total

1. Evidence that anabolic effects of PTH on bone require IGF-I in growing mice.

Authors: N Miyakoshi; Y Kasukawa; T A Linkhart; D J Baylink; S Mohan
Journal: Endocrinology Date: 2001-10 Impact factor: 4.736

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Journal: Ciba Found Symp Date: 1988

3. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

Authors: Dongsu Park; Joel A Spencer; Bong Ihn Koh; Tatsuya Kobayashi; Joji Fujisaki; Thomas L Clemens; Charles P Lin; Henry M Kronenberg; David T Scadden
Journal: Cell Stem Cell Date: 2012-03-02 Impact factor: 24.633

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Authors: R O Oreffo; G R Mundy; S M Seyedin; L F Bonewald
Journal: Biochem Biophys Res Commun Date: 1989-02-15 Impact factor: 3.575

5. Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells.

Authors: T Sobue; T Gravely; A Hand; Y K Min; C Pilbeam; L G Raisz; X Zhang; D Larocca; R Florkiewicz; M M Hurley
Journal: J Bone Miner Res Date: 2002-03 Impact factor: 6.741

6. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration.

Authors: Robert L Jilka; Maria Almeida; Elena Ambrogini; Li Han; Paula K Roberson; Robert S Weinstein; Starros C Manolagas
Journal: Aging Cell Date: 2010-10 Impact factor: 9.304

7. Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.

Authors: Vidya Ganapathy; Rongrong Ge; Alison Grazioli; Wen Xie; Whitney Banach-Petrosky; Yibin Kang; Scott Lonning; John McPherson; Jonathan M Yingling; Swati Biswas; Gregory R Mundy; Michael Reiss
Journal: Mol Cancer Date: 2010-05-26 Impact factor: 27.401

Review 8. Targeting the TGFβ signalling pathway in disease.

Authors: Rosemary J Akhurst; Akiko Hata
Journal: Nat Rev Drug Discov Date: 2012-09-24 Impact factor: 84.694

9. Integrin regulation by endogenous expression of 18-kDa fibroblast growth factor-2.

Authors: S Klein; A Bikfalvi; T M Birkenmeier; F G Giancotti; D B Rifkin
Journal: J Biol Chem Date: 1996-09-13 Impact factor: 5.157

Review 10. The hematopoietic stem cell niche.

Authors: Dongsu Park; David B Sykes; David T Scadden
Journal: Front Biosci (Landmark Ed) Date: 2012-01-01

138 in total

1. The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength.

Authors: Lingli Zhang; Xi Chen; Juanni Wu; Yu Yuan; Jianmin Guo; Soma Biswas; Baojie Li; Jun Zou
Journal: J Bone Miner Metab Date: 2016-06-29 Impact factor: 2.626

2. Role of MSC-derived galectin 3 in the AML microenvironment.

Authors: Peter P Ruvolo; Vivian R Ruvolo; Jared K Burks; YiHua Qiu; Rui-Yu Wang; Elizabeth J Shpall; Leonardo Mirandola; Numsen Hail; Zhihong Zeng; Teresa McQueen; Naval Daver; Sean M Post; Maurizio Chiriva-Internati; Steven M Kornblau; Michael Andreeff
Journal: Biochim Biophys Acta Mol Cell Res Date: 2018-04-12 Impact factor: 4.739

Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling.

1. Evidence that anabolic effects of PTH on bone require IGF-I in growing mice.

Review 2. Stromal stem cells: marrow-derived osteogenic precursors.

3. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

4. Activation of the bone-derived latent TGF beta complex by isolated osteoclasts.

5. Regulation of fibroblast growth factor 2 and fibroblast growth factor receptors by transforming growth factor beta in human osteoblastic MG-63 cells.

6. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration.

7. Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.

Review 8. Targeting the TGFβ signalling pathway in disease.

9. Integrin regulation by endogenous expression of 18-kDa fibroblast growth factor-2.

Review 10. The hematopoietic stem cell niche.

1. The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength.

2. Role of MSC-derived galectin 3 in the AML microenvironment.

3. Parathyroid hormone: critical bridge between bone metabolism and cardiovascular disease.

Review 4. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications.

Review 5. Coupling factors involved in preserving bone balance.

Review 6. Regulatory mechanisms of sclerostin expression during bone remodeling.

Review 7. Molecular and cellular basis of bone resorption.

8. Transforming growth factor-β in stem cells and tissue homeostasis.

9. The platelet: sensing shear and the endocrine regulation of cardiovascular sclerosis.

Review 10. More than the genes, the tumor microenvironment in neuroblastoma.