Daisuke Hashimoto1, Akira Chikamoto1, Masaki Ohmuraya2, Shinya Abe1, Shigeki Nakagawa1, Toru Beppu1, Hiroshi Takamori3, Masahiko Hirota4, Hideo Baba5. 1. Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Japan. 2. Institute of Resource Development and Analysis, Kumamoto University Graduate School of Medical Sciences, Japan. 3. Department of Surgery, Saiseikai Kumamoto Hospital, Japan. 4. Department of Surgery, Kumamoto Regional Medical Center, Japan. 5. Department of Gastroenterological Surgery, Kumamoto University Graduate School of Medical Sciences, Japan hdobaba@kumamoto-u.ac.jp.
Abstract
BACKGROUND: The aim of this study was to assess the effects of postoperative body weight loss on long-term survival after resection for pancreatic cancer. METHODS: A total of 93 patients with primary pancreatic cancer underwent pancreatic resection between April 2005 and December 2011. Patient characteristics, preoperative body mass index, and changes in postoperative body weight were evaluated retrospectively and correlated with long-term survival. RESULTS: There was no significant association between survival and preoperative body mass index. Body weight fell by 8.4% at 2 months after surgery and by 9.0% at 4 months after surgery. Severe postoperative body weight losses, both at 2 months (P = .033) and 4 months (P = .014) after surgery, were significantly associated with poor prognosis, especially among patients with stage IA-IIA pancreatic cancer (n = 43) (P = .005 at 2 months and P < .001 at 4 months). Additionally, severe body weight loss tended to be associated with shorter survival among patients with stage IIB-III pancreatic cancer (n = 50), although the difference was not significant. Multivariate analysis revealed that postoperative body weight loss was an independent prognostic factor. CONCLUSIONS: The results of this study demonstrated that pancreatic cancer patients with severe postoperative body weight loss have poorer postoperative outcomes.
BACKGROUND: The aim of this study was to assess the effects of postoperative body weight loss on long-term survival after resection for pancreatic cancer. METHODS: A total of 93 patients with primary pancreatic cancer underwent pancreatic resection between April 2005 and December 2011. Patient characteristics, preoperative body mass index, and changes in postoperative body weight were evaluated retrospectively and correlated with long-term survival. RESULTS: There was no significant association between survival and preoperative body mass index. Body weight fell by 8.4% at 2 months after surgery and by 9.0% at 4 months after surgery. Severe postoperative body weight losses, both at 2 months (P = .033) and 4 months (P = .014) after surgery, were significantly associated with poor prognosis, especially among patients with stage IA-IIA pancreatic cancer (n = 43) (P = .005 at 2 months and P < .001 at 4 months). Additionally, severe body weight loss tended to be associated with shorter survival among patients with stage IIB-III pancreatic cancer (n = 50), although the difference was not significant. Multivariate analysis revealed that postoperative body weight loss was an independent prognostic factor. CONCLUSIONS: The results of this study demonstrated that pancreatic cancerpatients with severe postoperative body weight loss have poorer postoperative outcomes.
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