Literature DB >> 24486571

Merging old and new perspectives on nicotinic acetylcholine receptors.

Roger L Papke1.   

Abstract

This review covers history underlying the discovery of the molecular mediators of nicotine's effects in the brain and the diversity of the nicotinic acetylcholine receptor (nAChR) subtypes. Models are presented for both their structure and their function as mediators of signal transduction, with special consideration of the differences between the two main subtypes: heteromeric receptors, which are specialized for rapid electrochemical signal transduction, and homomeric α7 receptors, which have come to be implicated in both ionotropic and metabotropic signaling. This review presents perspectives on the pharmacology and therapeutic targeting of nAChRs for the treatment of nicotine dependence or disease.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Allosteric proteins; Electrophysiology; Molecular biology; Signal transduction; Synaptic function

Mesh：

Substances：

Year:  2014        PMID： 24486571      PMCID： PMC4755309          DOI： 10.1016/j.bcp.2014.01.029

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  104 in total

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Review 2.  Structural and functional diversity of native brain neuronal nicotinic receptors.

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Journal:  Biochem Pharmacol       Date:  2009-05-27       Impact factor: 5.858

3.  Analysis of 3-(4-hydroxy, 2-Methoxybenzylidene)anabaseine selectivity and activity at human and rat alpha-7 nicotinic receptors.

Authors:  E M Meyer; A Kuryatov; V Gerzanich; J Lindstrom; R L Papke
Journal:  J Pharmacol Exp Ther       Date:  1998-12       Impact factor: 4.030

4.  Presynaptic modulation of transmitter release by nicotinic receptors.

Authors:  S Wonnacott; J Irons; C Rapier; B Thorne; G G Lunt
Journal:  Prog Brain Res       Date:  1989       Impact factor: 2.453

5.  The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery.

Authors:  Roger L Papke; Linda P Dwoskin; Peter A Crooks
Journal:  J Neurochem       Date:  2007-01-04       Impact factor: 5.372

6.  Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors.

Authors:  Nicole A Horenstein; Thomas J McCormack; Clare Stokes; Ke Ren; Roger L Papke
Journal:  J Biol Chem       Date:  2006-12-21       Impact factor: 5.157

Review 7.  Drug targets for cognitive enhancement in neuropsychiatric disorders.

Authors:  Tanya L Wallace; Theresa M Ballard; Bruno Pouzet; Wim J Riedel; Joseph G Wettstein
Journal:  Pharmacol Biochem Behav       Date:  2011-04-01       Impact factor: 3.533

8.  Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors.

Authors:  C W Luetje; J Patrick
Journal:  J Neurosci       Date:  1991-03       Impact factor: 6.167

9.  Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors.

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Review 10.  The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum.

Authors:  Sharon R Grady; Outi Salminen; Duncan C Laverty; Paul Whiteaker; J Michael McIntosh; Allan C Collins; Michael J Marks
Journal:  Biochem Pharmacol       Date:  2007-07-27       Impact factor: 5.858
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  79 in total

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Journal:  J Biol Chem       Date:  2015-08-04       Impact factor: 5.157

2.  Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.

Authors:  Nicole A Horenstein; Roger L Papke; Abhijit R Kulkarni; Ganesh U Chaturbhuj; Clare Stokes; Khan Manther; Ganesh A Thakur
Journal:  J Biol Chem       Date:  2016-01-07       Impact factor: 5.157

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4.  Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant β Subunits Acquire Sensitivity to α7-Selective Positive Allosteric Modulators.

Authors:  Clare Stokes; Sumanta Garai; Abhijit R Kulkarni; Lucas N Cantwell; Colleen M Noviello; Ryan E Hibbs; Nicole A Horenstein; Khalil A Abboud; Ganesh A Thakur; Roger L Papke
Journal:  J Pharmacol Exp Ther       Date:  2019-06-07       Impact factor: 4.030

Review 5.  Cholinergic interneurons in the dorsal and ventral striatum: anatomical and functional considerations in normal and diseased conditions.

Authors:  Kalynda K Gonzales; Yoland Smith
Journal:  Ann N Y Acad Sci       Date:  2015-04-15       Impact factor: 5.691

6.  Betel Nut (areca) and Smokeless Tobacco Use in Myanmar.

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7.  Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists Based on the Spirocyclic Quinuclidine-Δ2 -Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation.

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Journal:  ChemMedChem       Date:  2017-06-12       Impact factor: 3.466

8.  Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107.

Authors:  Marta Quadri; Sumanta Garai; Ganesh A Thakur; Clare Stokes; Alican Gulsevin; Nicole A Horenstein; Roger L Papke
Journal:  Mol Pharmacol       Date:  2018-10-22       Impact factor: 4.436

9.  B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation.

Authors:  Sumanta Garai; Krishnamohan S Raja; Roger L Papke; Jeffrey R Deschamps; M Imad Damaj; Ganesh A Thakur
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Review 10.  Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction.

Authors:  Ruthie E Wittenberg; Shannon L Wolfman; Mariella De Biasi; John A Dani
Journal:  Neuropharmacology       Date:  2020-07-29       Impact factor: 5.250
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