| Literature DB >> 24486518 |
Usha Pandey1, Mythili Kameswaran1, Haladhar Dev Sarma2, Grace Samuel3.
Abstract
The anti CD20 antibody Rituximab was conjugated with para isothiocyanato benzyl diethylene triamine penta acetic acid (p-NCS-Bz-DTPA) and subsequent radiolabeling with (99m)Tc was carried out via the (99m)Tc carbonyl synthon. The (99m)Tc labeled antibody conjugate exhibited >95% radiochemical purity after purification and retained good in vitro stability when studied up to 24h at room temperature. In vitro cell binding studies carried out in Raji cells expressing CD20 antigen validated the biological efficacy of the preparation.Entities:
Keywords: (99m)Tc carbonyl–DTPA–Rituximab; Non-Hodgkin's lymphoma (NHL); Radioimmunoscintigraphy; Rituximab
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Year: 2014 PMID： 24486518 DOI： 10.1016/j.apradiso.2013.12.036
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513