Literature DB >> 24486441

The pyruvate dehydrogenase complex of Corynebacterium glutamicum: an attractive target for metabolic engineering.

Bernhard J Eikmanns1, Bastian Blombach2.   

Abstract

The pyruvate dehydrogenase complex (PDHC) catalyzes the oxidative thiamine pyrophosphate-dependent decarboxylation of pyruvate to acetyl-CoA and CO2. Since pyruvate is a key metabolite of the central metabolism and also the precursor for several relevant biotechnological products, metabolic engineering of this multienzyme complex is a promising strategy to improve microbial production processes. This review summarizes the current knowledge and achievements on metabolic engineering approaches to tailor the PDHC of Corynebacterium glutamicum for the bio-based production of l-valine, 2-ketosiovalerate, pyruvate, succinate and isobutanol and to improve l-lysine production.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Amino and organic acid production; Corynebacterium glutamicum; Isobutanol production; Metabolic engineering; Pyruvate dehydrogenase complex

Mesh：

Substances：

Year:  2014        PMID： 24486441     DOI： 10.1016/j.jbiotec.2013.12.019

Source DB:  PubMed          Journal:  J Biotechnol        ISSN： 0168-1656            Impact factor:   3.307


  9 in total

1.  A novel aceE mutation leading to a better growth profile and a higher L-serine production in a high-yield L-serine-producing Corynebacterium glutamicum strain.

Authors:  Wen Guo; Ziwei Chen; Xiaomei Zhang; Guoqiang Xu; Xiaojuan Zhang; Jinsong Shi; Zhenghong Xu
Journal:  J Ind Microbiol Biotechnol       Date:  2016-06-25       Impact factor: 3.346

2.  Impact of CO2/HCO3 - Availability on Anaplerotic Flux in Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum Strains.

Authors:  Aileen Krüger; Johanna Wiechert; Cornelia Gätgens; Tino Polen; Regina Mahr; Julia Frunzke
Journal:  J Bacteriol       Date:  2019-09-20       Impact factor: 3.490

Review 3.  L-valine production in Corynebacterium glutamicum based on systematic metabolic engineering: progress and prospects.

Authors:  Jie Liu; Jian-Zhong Xu; Bingbing Wang; Zhi-Ming Rao; Wei-Guo Zhang
Journal:  Amino Acids       Date:  2021-08-16       Impact factor: 3.520

4.  Engineering Corynebacterium glutamicum for the production of 2,3-butanediol.

Authors:  Dušica Radoš; Ana Lúcia Carvalho; Stefan Wieschalka; Ana Rute Neves; Bastian Blombach; Bernhard J Eikmanns; Helena Santos
Journal:  Microb Cell Fact       Date:  2015-10-29       Impact factor: 5.328

5.  Effects of Host Plant and Insect Generation on Shaping of the Gut Microbiota in the Rice Leaffolder, Cnaphalocrocis medinalis.

Authors:  Yajun Yang; Xiaogai Liu; Hongxing Xu; Yinghong Liu; Zhongxian Lu
Journal:  Front Microbiol       Date:  2022-04-11       Impact factor: 5.640

Review 6.  Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species.

Authors:  Alberto Oliveira; Leticia C Oliveira; Flavia Aburjaile; Leandro Benevides; Sandeep Tiwari; Syed B Jamal; Arthur Silva; Henrique C P Figueiredo; Preetam Ghosh; Ricardo W Portela; Vasco A De Carvalho Azevedo; Alice R Wattam
Journal:  Front Microbiol       Date:  2017-10-12       Impact factor: 5.640

7.  Deciphering the Adaptation of Corynebacterium glutamicum in Transition from Aerobiosis via Microaerobiosis to Anaerobiosis.

Authors:  Julian Lange; Eugenia Münch; Jan Müller; Tobias Busche; Jörn Kalinowski; Ralf Takors; Bastian Blombach
Journal:  Genes (Basel)       Date:  2018-06-13       Impact factor: 4.096

8.  Production of the compatible solute α-D-glucosylglycerol by metabolically engineered Corynebacterium glutamicum.

Authors:  Benjamin Roenneke; Natalie Rosenfeldt; Sami M Derya; Jens F Novak; Kay Marin; Reinhard Krämer; Gerd M Seibold
Journal:  Microb Cell Fact       Date:  2018-06-16       Impact factor: 5.328

9.  Proteome analysis guided genetic engineering of Corynebacterium glutamicum S9114 for tween 40-triggered improvement in L-ornithine production.

Authors:  Yan Jiang; Ming-Zhu Huang; Xue-Lan Chen; Bin Zhang
Journal:  Microb Cell Fact       Date:  2020-01-06       Impact factor: 5.328
  9 in total

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