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Literature DB >> 24486289

Individual and composite study endpoints: separating the wheat from the chaff.

Robert Goldberg¹, Joel M Gore², Bruce Barton³, Jerry Gurwitz⁴.

Abstract

We provide an overview of the individual and combined clinical endpoints and patient-reported outcomes typically used in clinical trials and prospective epidemiological investigations. We discuss the strengths and limitations associated with the utilization of aggregated study endpoints and surrogate measures of important clinical endpoints and patient-centered outcomes. We hope that the points raised in this overview will lead to the collection of clinically rich, relevant, measurable, and cost-efficient study outcomes.

Entities: Chemical Disease Gene Species

Keywords: Clinical epidemiology; Study design; Study outcomes and endpoints

Mesh：

Year: 2014 PMID： 24486289 PMCID： PMC4019929 DOI： 10.1016/j.amjmed.2014.01.011

Source DB: PubMed Journal: Am J Med ISSN： 0002-9343 Impact factor: 4.965

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