Literature DB >> 24486152

A single-centre cost comparison analysis of collagenase injection versus surgical fasciectomy for Dupuytren's contracture of the hand.

S Mehta1, H J C R Belcher2.   

Abstract

BACKGROUND AND AIM: The options for treating patients with Dupuytren's contracture have broadened with the introduction of collagenase. Although the literature would suggest that collagenase treatment is effective, has few complications and is popular with patients, it has not been widely commissioned by the National Health Services of the United Kingdom and other European countries due to concerns about cost. The aim of this study was to compare the cost of surgical fasciectomy to collagenase injections for the treatment of Dupuytren's contracture in a single centre.
METHOD: Prospective data on 40 patients undergoing fasciectomy or collagenase injection (20 patients in each group) were collected between January and March 2013. Financial data on the costs of the procedures, equipment, theatre time and follow-up appointments were calculated.
RESULTS: The average cost of an open partial fasciectomy pathway was £ 7115.34 and that of a collagenase pathway was £ 2110.62. Eight collagenase patients had physician-led follow-up appointments and only three had hand physiotherapy appointments. By contrast, every fasciectomy patient had at least one physician and one physiotherapist follow-up appointment routinely.
CONCLUSION: The results of this study demonstrate that collagenase treatment for Dupuytren's contracture of a single digit in selected patients is just over £ 5000 less than treatment for the same condition using surgical fasciectomy. Collagenase-treated patients require much less physician- and physiotherapist-led postoperative follow-up.
Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Collagenase; Cost; Dupuytren's contracture; Fasciectomy

Mesh:

Substances:

Year:  2014        PMID: 24486152     DOI: 10.1016/j.bjps.2013.12.030

Source DB:  PubMed          Journal:  J Plast Reconstr Aesthet Surg        ISSN: 1748-6815            Impact factor:   2.740


  12 in total

Review 1.  Trends in the Treatment of Dupuytren Disease in the United States Between 2007 and 2014.

Authors:  Marc D Lipman; Samuel Evan Carstensen; Dylan Nicole Deal
Journal:  Hand (N Y)       Date:  2016-05-03

2.  Clinical outcomes following collagenase injections compared to fasciectomy in the treatment of Dupuytren's contracture.

Authors:  Raghuveer C Muppavarapu; Michael J Waters; Matthew I Leibman; Mark R Belsky; David E Ruchelsman
Journal:  Hand (N Y)       Date:  2015-06

Review 3.  Collagenase Treatment in Dupuytren Contractures: A Review of the Current State Versus Future Needs.

Authors:  Ilse Degreef
Journal:  Rheumatol Ther       Date:  2016-02-03

4.  [Treatment of Dupuytren's disease with collagenase Clostridium histolyticum].

Authors:  M Keller; R Arora; G Schmiedle; T Kastenberger
Journal:  Orthopade       Date:  2017-04       Impact factor: 1.087

Review 5.  Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review.

Authors:  Francesco Smeraglia; Angelo Del Buono; Nicola Maffulli
Journal:  Br Med Bull       Date:  2016-05-05       Impact factor: 4.291

6.  Systematic Review Comparing Cost Analyses of Fasciectomy, Needle Aponeurotomy, and Collagenase Injection for Treatment of Dupuytren's Contracture: Une analyse de coûts systématique comparant la fasciectomie, l'aponévrotomie percutanée à l'aiguille et l'injection de collagénase pou traiter la maladie de Dupuytren.

Authors:  Alanna Victoria Fitzpatrick; Syena Moltaji; Maleka Ramji; Stuart Martin
Journal:  Plast Surg (Oakv)       Date:  2020-10-16       Impact factor: 0.947

7.  Percutaneous Needle Fasciotomy versus Collagenase Injection for Dupuytren's Contracture: A Systematic Review of Comparative Studies.

Authors:  Takashi Hirase; Rishi Suresh; Michael O Cotton; Alex Han; Matthew B Burn; Joshua D Harris; Shari R Liberman
Journal:  J Hand Microsurg       Date:  2020-12-31

8.  DupuytrEn Treatment EffeCtiveness Trial (DETECT): a protocol for prospective, randomised, controlled, outcome assessor-blinded, three-armed parallel 1:1:1, multicentre trial comparing the effectiveness and cost of collagenase clostridium histolyticum, percutaneous needle fasciotomy and limited fasciectomy as short-term and long-term treatment strategies in Dupuytren's contracture.

Authors:  Mikko P Räisänen; Teemu Karjalainen; Harry Göransson; Aleksi Reito; Hannu Kautiainen; Antti Malmivaara; Olli V Leppänen
Journal:  BMJ Open       Date:  2018-03-28       Impact factor: 2.692

9.  Cost-Effectiveness and Patient Outcomes of Injectable Collagenase to Treat Dupuytren's Contracture.

Authors:  Rajpreet S Sahemey; Govind S Dhillon; Karanjeet S Sagoo; Kuntrapaka Srinivas
Journal:  Cureus       Date:  2021-12-20

10.  Healthcare Costs and Resource Use of Patients with Dupuytren Contracture Treated with Collagenase Clostridium Histolyticum or Fasciectomy: A Propensity Matching Analysis.

Authors:  Vladimir Zah; Jovana Pelivanovic; Simona Tatovic; Djurdja Vukicevic; Martina Imro; Jane Ruby; David Hurley
Journal:  Clinicoecon Outcomes Res       Date:  2020-11-04
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