| Literature DB >> 24485783 |
Polyana A de Assis1, Phellipe N E T Theodoro1, José E de Paula2, Ana J Araújo3, Letícia V Costa-Lotufo3, Sylvie Michel4, Raphaël Grougnet4, Marina Kritsanida5, Laila S Espindola6.
Abstract
Since the 1960s, fungal infections have become a major worldwide public health problem. Antifungal treatments have many limitations, such as toxicity and resistance. Matayba guianensis Aublet (Sapindaceae) was chemically investigated as part of our ongoing search for lead molecules against fungi in the Brazilian Cerrado biome. The ethanolic extract of M. guianensis root bark revealed the presence of two previously unreported ether diglycosides: matayoside E (1) and F (2) with anti Candida activity, along with two known compounds: cupanioside (3) and stigmasterol (4).Entities:
Keywords: Antifungal activity; Brazilian Cerrado; Ether diglycosides; Matayba guianensis; Matayosides E and F
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Year: 2014 PMID： 24485783 DOI： 10.1016/j.bmcl.2014.01.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823