Literature DB >> 24485344

Cohort study of diabetes in HIV-infected adult patients: evaluating the effect of diabetes mellitus on immune reconstitution.

D Moyo1, G Tanthuma1, M S Cary2, O Mushisha1, G Kwadiba1, F Chikuse1, A P Steenhoff3, M J A Reid4.   

Abstract

We conducted a retrospective cohort study assessing the association between diabetes mellitus (DM) and immune recovery in HIV-infected adults. Immune reconstitution after initiating antiretroviral therapy was more rapid in DM patients (120.4 cells/year) compared to non-DM patients (94.2 cells/year, p<0.023). Metformin use was associated with improved CD4 recovery (p=0.034).
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  CD4 count; HIV; Immune reconstitution; Metformin

Mesh：

Substances：

Year:  2014        PMID： 24485344      PMCID： PMC3989401          DOI： 10.1016/j.diabres.2013.12.042

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


  6 in total

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Authors:  David R Whiting; Leonor Guariguata; Clara Weil; Jonathan Shaw
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2.  Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome.

Authors:  Kathleen Fitch; Suhny Abbara; Hang Lee; Eleni Stavrou; Rachel Sacks; Theresa Michel; Linda Hemphill; Martin Torriani; Steven Grinspoon
Journal:  AIDS       Date:  2012-03-13       Impact factor: 4.177

3.  Effect of nonnucleoside reverse transcriptase inhibitor-based antiretroviral therapy on dysglycemia and insulin sensitivity in South African HIV-infected patients.

Authors:  Joel A Dave; Estelle V Lambert; Motasim Badri; Sacha West; Gary Maartens; Naomi S Levitt
Journal:  J Acquir Immune Defic Syndr       Date:  2011-08-01       Impact factor: 3.731

4.  Expansion of CD4+CD28null T-lymphocytes in diabetic patients: exploring new pathogenetic mechanisms of increased cardiovascular risk in diabetes mellitus.

Authors:  Simona Giubilato; Giovanna Liuzzo; Salvatore Brugaletta; Dario Pitocco; Francesca Graziani; Costantino Smaldone; Rocco Antonio Montone; Vincenzo Pazzano; Daniela Pedicino; Luigi Marzio Biasucci; Giovanni Ghirlanda; Filippo Crea
Journal:  Eur Heart J       Date:  2011-01-08       Impact factor: 29.983

5.  The efficacy and safety of insulin-sensitizing drugs in HIV-associated lipodystrophy syndrome: a meta-analysis of randomized trials.

Authors:  Siddharth H Sheth; Robin J Larson
Journal:  BMC Infect Dis       Date:  2010-06-23       Impact factor: 3.090

6.  Metformin: a cheap and well-tolerated drug that provides benefits for viral infections.

Authors:  J Joven; J A Menéndez; L Fernandez-Sender; E Espinel; A Rull; R Beltrán-Debón; E Rodríguez-Gallego; M Riera-Borrull; J Pedro-Botet; C Alonso-Villaverde; J Camps; G Aragonès
Journal:  HIV Med       Date:  2012-11-21       Impact factor: 3.180
  6 in total
  11 in total

Review 1.  Epidemiology, pathophysiology, and prevention of heart failure in people with HIV.

Authors:  Arjun Sinha; Matthew Feinstein
Journal:  Prog Cardiovasc Dis       Date:  2020-01-24       Impact factor: 8.194

2.  A Summary of the Fifth Annual Virology Education HIV Microbiome Workshop.

Authors:  Scott Sherrill-Mix; Kaleigh Connors; Grace M Aldrovandi; Jason M Brenchley; Charles Boucher; Frederic D Bushman; Ronald G Collman; Satya Dandekar; Nichole R Klatt; Laurel A Lagenaur; Roger Paredes; Gilda Tachedjian; Jim A Turpin; Alan L Landay; Mimi Ghosh
Journal:  AIDS Res Hum Retroviruses       Date:  2020-09-07       Impact factor: 2.205

3.  Elevated CD4 + T-cell glucose metabolism in HIV+ women with diabetes mellitus.

Authors:  Tiffany R Butterfield; David B Hanna; Robert C Kaplan; Xiaonan Xue; Jorge R Kizer; Helen G Durkin; Seble G Kassaye; Marek Nowicki; Phyllis C Tien; Elizabeth T Topper; Michelle A Floris-Moore; Kehmia Titanji; Margaret A Fischl; Sonya Heath; Clovis S Palmer; Alan L Landay; Joshua J Anzinger
Journal:  AIDS       Date:  2022-06-21       Impact factor: 4.632

4.  Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol.

Authors:  Jean-Pierre Routy; Stéphane Isnard; Vikram Mehraj; Mario Ostrowski; Nicolas Chomont; Petronela Ancuta; Rosalie Ponte; Delphine Planas; Franck P Dupuy; Jonathan B Angel
Journal:  BMJ Open       Date:  2019-04-20       Impact factor: 2.692

Review 5.  Specific Biological Features of Adipose Tissue, and Their Impact on HIV Persistence.

Authors:  Christine Bourgeois; Jennifer Gorwood; Aurélie Barrail-Tran; Claire Lagathu; Jacqueline Capeau; Delphine Desjardins; Roger Le Grand; Abderaouf Damouche; Véronique Béréziat; Olivier Lambotte
Journal:  Front Microbiol       Date:  2019-12-17       Impact factor: 5.640

6.  Metformin is Associated with Decreased 30-Day Mortality Among Nursing Home Residents Infected with SARS-CoV2.

Authors:  Michelle A Lally; Philip Tsoukas; Christopher W Halladay; Emily O'Neill; Stefan Gravenstein; James L Rudolph
Journal:  J Am Med Dir Assoc       Date:  2020-10-26       Impact factor: 4.669

7.  Multi-omics analyses reveal that HIV-1 alters CD4+ T cell immunometabolism to fuel virus replication.

Authors:  Haitao Guo; Qi Wang; Khader Ghneim; Li Wang; Elena Rampanelli; Elizabeth Holley-Guthrie; Liang Cheng; Carolina Garrido; David M Margolis; Leigh A Eller; Merlin L Robb; Rafick-Pierre Sekaly; Xian Chen; Lishan Su; Jenny P-Y Ting
Journal:  Nat Immunol       Date:  2021-03-25       Impact factor: 25.606

8.  Risk Factors for Incident Diabetes in a Cohort Taking First-Line Nonnucleoside Reverse Transcriptase Inhibitor-Based Antiretroviral Therapy.

Authors:  Sumanth Karamchand; Rory Leisegang; Michael Schomaker; Gary Maartens; Lourens Walters; Michael Hislop; Joel A Dave; Naomi S Levitt; Karen Cohen
Journal:  Medicine (Baltimore)       Date:  2016-03       Impact factor: 1.889

Review 9.  Metformin effect on gut microbiota: insights for HIV-related inflammation.

Authors:  Jing Ouyang; Stéphane Isnard; John Lin; Brandon Fombuena; André Marette; Bertrand Routy; Yaokai Chen; Jean-Pierre Routy
Journal:  AIDS Res Ther       Date:  2020-03-10       Impact factor: 2.250

Review 10.  HIV-1 Infection and Glucose Metabolism Reprogramming of T Cells: Another Approach Toward Functional Cure and Reservoir Eradication.

Authors:  Shuang Kang; Hong Tang
Journal:  Front Immunol       Date:  2020-10-07       Impact factor: 7.561
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