Stewart Harris1, Muhammad Mamdani2, Claus B Galbo-Jørgensen3, Mette Bøgelund3, Jens Gundgaard4, Danielle Groleau5. 1. Department of Family Medicine, Western University, London, Ontario, Canada. Electronic address: sharris1@uwo.ca. 2. Applied Health Research Centre (AHRC), Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada; Institute of Health Policy, Management, and Evaluation and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada. 3. Incentive Partners, Holte, Denmark. 4. Novo Nordisk A/S, Søborg, Denmark. 5. Novo Nordisk Canada Inc, Mississauga, Ontario, Canada.
Abstract
OBJECTIVE: The aim of this study was to investigate the impact of hypoglycemia according to severity and time of onset on health-related quality of life (HRQoL) in a Canadian population. METHODS: Time trade-off (TTO) methodology was used to estimate health utilities associated with hypoglycemic events in a representative sample of the Canadian population. A global analysis conducted in the United Kingdom, Canada, Germany and Sweden has been published. The present Canadian analysis focuses on 3 populations: general, type 1 and type 2 diabetes. Using a web-based survey, participants (>18 years) assessed the utility of 13 different health states (severe, non-severe, daytime and nocturnal hypoglycemia at different frequencies) using a scale from 1 (perfect health) to 0 (death). The average disutility value for each type of event was calculated. RESULTS: Of 2258 participants, 1696 completers were included in the analysis. A non-severe nocturnal hypoglycemic event was associated with a significantly greater disutility than a non-severe daytime event (-0.0076 vs. -0.0056, respectively; p=0.05), while there was no statistically significant difference between severe nocturnal and severe daytime events (-0.0616 vs. -0.0592; p=0.76). Severe hypoglycemia was associated with greater disutility than non-severe hypoglycemia (p<0.0001). Similar trends were reported in participants with diabetes. CONCLUSIONS: The findings presented here show that any form of hypoglycemia had a negative impact on HRQoL in a Canadian population. Nocturnal and/or severe hypoglycemia had a greater negative impact on HRQoL compared with daytime and/or non-severe events. This highlights the importance of preventing the development and nocturnal manifestation of hypoglycemia in patients with diabetes.
OBJECTIVE: The aim of this study was to investigate the impact of hypoglycemia according to severity and time of onset on health-related quality of life (HRQoL) in a Canadian population. METHODS: Time trade-off (TTO) methodology was used to estimate health utilities associated with hypoglycemic events in a representative sample of the Canadian population. A global analysis conducted in the United Kingdom, Canada, Germany and Sweden has been published. The present Canadian analysis focuses on 3 populations: general, type 1 and type 2 diabetes. Using a web-based survey, participants (>18 years) assessed the utility of 13 different health states (severe, non-severe, daytime and nocturnal hypoglycemia at different frequencies) using a scale from 1 (perfect health) to 0 (death). The average disutility value for each type of event was calculated. RESULTS: Of 2258 participants, 1696 completers were included in the analysis. A non-severe nocturnal hypoglycemic event was associated with a significantly greater disutility than a non-severe daytime event (-0.0076 vs. -0.0056, respectively; p=0.05), while there was no statistically significant difference between severe nocturnal and severe daytime events (-0.0616 vs. -0.0592; p=0.76). Severe hypoglycemia was associated with greater disutility than non-severe hypoglycemia (p<0.0001). Similar trends were reported in participants with diabetes. CONCLUSIONS: The findings presented here show that any form of hypoglycemia had a negative impact on HRQoL in a Canadian population. Nocturnal and/or severe hypoglycemia had a greater negative impact on HRQoL compared with daytime and/or non-severe events. This highlights the importance of preventing the development and nocturnal manifestation of hypoglycemia in patients with diabetes.
Authors: Wen Wan; M Reza Skandari; Alexa Minc; Aviva G Nathan; Parmida Zarei; Aaron N Winn; Michael O'Grady; Elbert S Huang Journal: Med Decis Making Date: 2018-11 Impact factor: 2.583
Authors: Neda Laiteerapong; Jennifer M Cooper; M Reza Skandari; Philip M Clarke; Aaron N Winn; Rochelle N Naylor; Elbert S Huang Journal: Ann Intern Med Date: 2017-12-12 Impact factor: 25.391
Authors: Darrell M Wilson; Peter M Calhoun; David M Maahs; H Peter Chase; Laurel Messer; Bruce A Buckingham; Tandy Aye; Paula K Clinton; Irene Hramiak; Craig Kollman; Roy W Beck Journal: Diabetes Technol Ther Date: 2015-03-11 Impact factor: 6.118
Authors: Marie M Henriksen; Henrik U Andersen; Birger Thorsteinsson; Ulrik Pedersen-Bjergaard Journal: Diabetologia Date: 2021-01-14 Impact factor: 10.122
Authors: Jayne Smith-Palmer; Jay P Bae; Kristina S Boye; Kirsi Norrbacka; Barnaby Hunt; William J Valentine Journal: Clinicoecon Outcomes Res Date: 2016-10-07