M Ammar1, C Bouchlaka-Souissi2, K Soumaya2, R Bouhaha2, Z Ines3, F Bouazizi2, N Doss4, R Dhaoui4, A Ben Osman3, A Ben Ammar-El Gaaïed2, M Mokni3, R Marrakchi2. 1. Laboratory of Genetics, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Campus Universitaire, El Manar, 2092 Tunis, Tunisia. Electronic address: myriambensaid@yahoo.fr. 2. Laboratory of Genetics, Immunology and Human Pathologies, Department of Biology, Faculty of Sciences, Campus Universitaire, El Manar, 2092 Tunis, Tunisia. 3. Department of Dermatology, La Rabta Hospital, La Rabta, 1007 Tunis, Tunisia. 4. Department of Dermatology, Military Hospital of Tunis, Montfleury, Tunis, Tunisia.
Abstract
BACKGROUND: Recently, it has been shown that a deletion in the late cornified envelope (LCE) gene cluster (LCE3C_LCE3B-del) is associated with susceptibility to psoriasis in European and Asian populations. However, no study of this deletion has been performed in the North African population. The aim of the present study was to investigate whether this deletion is associated with familial psoriasis in Tunisian population. METHODS: A total of 34 patients and 55 healthy individuals were recruited from 7 multiplex families and a PCR assay was used to determine the association of this deletion. Its effect on susceptibility to psoriasis was assessed using the PDT program. RESULTS: We failed to detect any evidence of association between LCE3C_LCE3B-del and psoriasis in Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus. CONCLUSIONS: These findings indicate that the LCE3C_LCE3B-del does not contribute in a major way to psoriasis susceptibility in Tunisian families.
BACKGROUND: Recently, it has been shown that a deletion in the late cornified envelope (LCE) gene cluster (LCE3C_LCE3B-del) is associated with susceptibility to psoriasis in European and Asian populations. However, no study of this deletion has been performed in the North African population. The aim of the present study was to investigate whether this deletion is associated with familial psoriasis in Tunisian population. METHODS: A total of 34 patients and 55 healthy individuals were recruited from 7 multiplex families and a PCR assay was used to determine the association of this deletion. Its effect on susceptibility to psoriasis was assessed using the PDT program. RESULTS: We failed to detect any evidence of association between LCE3C_LCE3B-del and psoriasis in Tunisian families. No epistasic effect was found between the deletion and PSORS1 locus. CONCLUSIONS: These findings indicate that the LCE3C_LCE3B-del does not contribute in a major way to psoriasis susceptibility in Tunisian families.
Keywords:
Copy number variation; Family-based association study; Gene interaction; Genetics; Génétique; Interaction gène-gène; Psoriasis; Variation de nombre de copies; Étude d’association basée sur des familles