Benedicte Rønning1, Torgeir Bruun Wyller2, Marit Slaaen Jordhøy3, Arild Nesbakken4, Arne Bakka5, Ingebjørg Seljeflot6, Siri Rostoft Kristjansson7. 1. Department of Geriatric Medicine, Oslo University Hospital, Pb 4956 Nydalen, 0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: benedroning@gmail.com. 2. Department of Geriatric Medicine, Oslo University Hospital, Pb 4956 Nydalen, 0424 Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 3. Department of Internal Medicine, Innlandet Hospital Trust Gjøvik, Gjøvik, Norway; Regional Center of Excellence in Palliative Care, Oslo University Hospital, Oslo, Norway. 4. Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Gastroenterological Surgery, Oslo University Hospital, Oslo, Norway. 5. Department of Digestive Surgery, Akershus University Hospital, University of Oslo, Lorenskog, Norway. 6. Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway. 7. Department of Geriatric Medicine, Oslo University Hospital, Pb 4956 Nydalen, 0424 Oslo, Norway; Diakonhjemmet Hospital, Department of Medicine, Diakonvn 12, 0319 Oslo, Norway.
Abstract
OBJECTIVES: The number of older survivors from colorectal cancer is increasing, but little is known regarding long-term consequences of cancer treatment in this patient group. Physical function is an important outcome for older patients, affecting both autonomy and quality of life. We aimed to investigate physical function in older patients with colorectal cancer before and after surgery, and to examine the role of individual frailty indicators as predictors of functional decline. MATERIAL AND METHODS: We present 16-28 months follow-up data of older patients after elective surgery for colorectal cancer. During a home-visit, physical function was evaluated by activities of daily living (ADL), instrumental activities of daily living (IADL), the timed up-and-go (TUG) test, and grip strength. Measurements were compared with those obtained preoperatively using the Wilcoxon signed rank test. Frailty indicators were dichotomized and implemented in logistic regression models to explore their associations to a decline in the physical function scores. RESULTS: Eighty-four patients were included and the median age was 82 years. There was a significant decrease in ADL (p = 0.04) and IADL scores (p ≤ 0.001) at follow-up. We found no associations between frailty indicators and the risk of decline in physical functioning. CONCLUSION: In our population of older patients with surgically treated colorectal cancer, there was a significant decline in ADL- and IADL-scores at follow-up. No change was found in TUG or grip strength, and frailty indicators did not predict decline in physical function.
OBJECTIVES: The number of older survivors from colorectal cancer is increasing, but little is known regarding long-term consequences of cancer treatment in this patient group. Physical function is an important outcome for older patients, affecting both autonomy and quality of life. We aimed to investigate physical function in older patients with colorectal cancer before and after surgery, and to examine the role of individual frailty indicators as predictors of functional decline. MATERIAL AND METHODS: We present 16-28 months follow-up data of older patients after elective surgery for colorectal cancer. During a home-visit, physical function was evaluated by activities of daily living (ADL), instrumental activities of daily living (IADL), the timed up-and-go (TUG) test, and grip strength. Measurements were compared with those obtained preoperatively using the Wilcoxon signed rank test. Frailty indicators were dichotomized and implemented in logistic regression models to explore their associations to a decline in the physical function scores. RESULTS: Eighty-four patients were included and the median age was 82 years. There was a significant decrease in ADL (p = 0.04) and IADL scores (p ≤ 0.001) at follow-up. We found no associations between frailty indicators and the risk of decline in physical functioning. CONCLUSION: In our population of older patients with surgically treated colorectal cancer, there was a significant decline in ADL- and IADL-scores at follow-up. No change was found in TUG or grip strength, and frailty indicators did not predict decline in physical function.
Authors: L Decoster; C Kenis; D Schallier; J Vansteenkiste; K Nackaerts; L Vanacker; N Vandewalle; J Flamaing; J P Lobelle; K Milisen; J De Grève; H Wildiers Journal: Lung Date: 2017-06-20 Impact factor: 2.584
Authors: Mitsunori Nakano; Yohei Nomura; Giancarlo Suffredini; Brian Bush; Jing Tian; Atsushi Yamaguchi; Jeremy Walston; Rani Hasan; Kaushik Mandal; Stefano Schena; Charles W Hogue; Charles H Brown Journal: Anesth Analg Date: 2020-06 Impact factor: 5.108
Authors: Brandon M Meyers; Humaid O Al-Shamsi; Sara Rask; Radhika Yelamanchili; Callista M Phillips; Alexandra Papaioannou; Gregory R Pond; Neera Jeyabalan; Kevin M Zbuk; Sukhbinder Kaur Dhesy-Thind Journal: J Gastrointest Oncol Date: 2017-02