Aifang Yang1, Bin Wang2, Guoxing Zhu3, Zheng Jiao4, Youxin Fang3, Fengmin Tang4, Chunlai Ma4, Yue Zhao4, Cai Cheng4, Mingkang Zhong4. 1. Department of Pharmacy, HuaShan Hospital, Fudan University, Shanghai, China. Electronic address: beekelvin2003@hotmail.com. 2. Department of Pharmacy, HuaShan Hospital, Fudan University, Shanghai, China. Electronic address: bywang1966@gmail.com. 3. Department of Neurology, HuaShan Hospital, Fudan University, Shanghai, China. 4. Department of Pharmacy, HuaShan Hospital, Fudan University, Shanghai, China.
Abstract
PURPOSE: This study aimed to validate a Chinese version of the Morisky Medication Adherence Scale (MMAS-8) in patients with epilepsy. The relationships between adherence, seizure frequency, and adverse effects were assessed using this method. METHODS: Data from patients diagnosed with epilepsy at the Department of Neurology of Huashan Hospital were collected between January and June 2013. To validate the MMAS-8, internal consistency, test-retest reliability, and factor analysis were calculated. Relationships between adherence, seizure frequency, and adverse effects were assessed using Pearson's correlation. RESULTS: One hundred and eleven patients were recruited. The MMAS-8 had moderate internal consistency (Cronbach's α=0.556) and good test-retest reliability (intraclass correlation coefficient=0.729). The MMAS-8 adherence rate was 79.2%. MMAS-8 adherence was negatively correlated with seizure frequency and adverse effects (r = -0.708, p<0.001; r = -0.484, p<0.001). CONCLUSION: The MMAS-8 scale can be used as a tool to assess medication adherence in Chinese patients with epilepsy. Better seizure control and lower rates of adverse effects were significantly correlated with higher adherence scores.
PURPOSE: This study aimed to validate a Chinese version of the Morisky Medication Adherence Scale (MMAS-8) in patients with epilepsy. The relationships between adherence, seizure frequency, and adverse effects were assessed using this method. METHODS: Data from patients diagnosed with epilepsy at the Department of Neurology of Huashan Hospital were collected between January and June 2013. To validate the MMAS-8, internal consistency, test-retest reliability, and factor analysis were calculated. Relationships between adherence, seizure frequency, and adverse effects were assessed using Pearson's correlation. RESULTS: One hundred and eleven patients were recruited. The MMAS-8 had moderate internal consistency (Cronbach's α=0.556) and good test-retest reliability (intraclass correlation coefficient=0.729). The MMAS-8 adherence rate was 79.2%. MMAS-8 adherence was negatively correlated with seizure frequency and adverse effects (r = -0.708, p<0.001; r = -0.484, p<0.001). CONCLUSION: The MMAS-8 scale can be used as a tool to assess medication adherence in Chinese patients with epilepsy. Better seizure control and lower rates of adverse effects were significantly correlated with higher adherence scores.
Authors: Yun Mi Yu; Euni Lee; Bon Sun Koo; Kyeong Hye Jeong; Kyung Hee Choi; Lee Kyung Kang; Mo Se Lee; Kwang Hoon Choi; Jung Mi Oh; Wan Gyoon Shin Journal: PLoS One Date: 2016-05-18 Impact factor: 3.240
Authors: J Hu; D Z Yuan; Q Y Zhao; X F Wang; X T Zhang; Q H Jiang; H R Luo; J Li; J H Ran; J F Li Journal: BMC Med Inform Decis Mak Date: 2020-08-11 Impact factor: 2.796