INTRODUCTION: The accumulation of visceral fat affects the metabolism of hormones and some nutrients, but these mechanisms remain unclear. OBJECTIVE: To assess the influence of cortisol on the metabolism of zinc in morbidly obese women. METHOD: Cross-sectional, case-control study involving 80 women aged between 20 and 59 years. The participants were divided into two groups: experimental (morbidly obese, n = 40) and control (normal weight, n = 40). Zinc concentrations were determined by atomic absorption spectroscopy and serum and urinary cortisol by chemiluminescence method. RESULTS: Zinc intake was significantly different between groups. Mean plasma zinc was lower in obese compared to control group. Mean values for erythrocyte zinc were 44.52 ± 7.84 µg/gHb and 40.17 ± 6.71 µg/gHb for obese and control groups, respectively. Urinary excretion of this mineral was higher in obese compared to control subjects (p < 0.05). Mean values for plasma cortisol were 9.58 ± 4.86 µg/dL for obese and 9.89 ± 5.61 µg/dL for control groups. Mean values for urinary cortisol were 163.00 ± 100.35 µg/dL and 109.71 ± 34.88 µg/dL for obese and control groups, respectively (p > 0.05). The correlation analysis between cortisol and zinc was not significant (p > 0.05). CONCLUSIONS: Obese patients have hypozincemia and high erythrocyte zinc levels. The correlation between zinc parameters and cortisol concentration showed no influence of this hormone on zinc metabolism.
INTRODUCTION: The accumulation of visceral fat affects the metabolism of hormones and some nutrients, but these mechanisms remain unclear. OBJECTIVE: To assess the influence of cortisol on the metabolism of zinc in morbidly obesewomen. METHOD: Cross-sectional, case-control study involving 80 women aged between 20 and 59 years. The participants were divided into two groups: experimental (morbidly obese, n = 40) and control (normal weight, n = 40). Zinc concentrations were determined by atomic absorption spectroscopy and serum and urinary cortisol by chemiluminescence method. RESULTS: Zinc intake was significantly different between groups. Mean plasma zinc was lower in obese compared to control group. Mean values for erythrocyte zinc were 44.52 ± 7.84 µg/gHb and 40.17 ± 6.71 µg/gHb for obese and control groups, respectively. Urinary excretion of this mineral was higher in obese compared to control subjects (p < 0.05). Mean values for plasma cortisol were 9.58 ± 4.86 µg/dL for obese and 9.89 ± 5.61 µg/dL for control groups. Mean values for urinary cortisol were 163.00 ± 100.35 µg/dL and 109.71 ± 34.88 µg/dL for obese and control groups, respectively (p > 0.05). The correlation analysis between cortisol and zinc was not significant (p > 0.05). CONCLUSIONS:Obesepatients have hypozincemia and high erythrocyte zinc levels. The correlation between zinc parameters and cortisol concentration showed no influence of this hormone on zinc metabolism.
Authors: Judit Tenk; Péter Mátrai; Péter Hegyi; Ildikó Rostás; András Garami; Imre Szabó; Margit Solymár; Erika Pétervári; József Czimmer; Katalin Márta; Alexandra Mikó; Nóra Füredi; Andrea Párniczky; Csaba Zsiborás; Márta Balaskó Journal: PLoS One Date: 2016-11-21 Impact factor: 3.240
Authors: Erika P S Freitas; Aline T O Cunha; Sephora L S Aquino; Lucia F C Pedrosa; Severina C V C Lima; Josivan G Lima; Maria G Almeida; Karine C M Sena-Evangelista Journal: Nutrients Date: 2017-02-22 Impact factor: 5.717