Literature DB >> 24482496

Delta-1 provides pleasant stem cell environs.

Louis M Pelus1, Pratibha Singh.   

Abstract

In this issue of Blood, Csaszar et al show that in ex vivo cultures of CD341 cells, simultaneous reduction of interleukin-6 receptor (IL-6R) expression on myeloid progenitor cells by Delta-1 treatment combined with removal of soluble IL-6R using a dynamically fed culture system, reduces mature myeloid cell production, leading to enhanced expansion of primitive hematopoietic stem cells.

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Year:  2014        PMID： 24482496      PMCID： PMC3907749          DOI： 10.1182/blood-2013-12-539841

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  9 in total

1.  Differential response of primitive human CD34- and CD34+ hematopoietic cells to the Notch ligand Jagged-1.

Authors:  F N Karanu; L Yuefei; L Gallacher; S Sakano; M Bhatia
Journal:  Leukemia       Date:  2003-07       Impact factor: 11.528

2.  Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.

Authors:  Elizabeth Csaszar; Daniel C Kirouac; Mei Yu; WeiJia Wang; Wenlian Qiao; Michael P Cooke; Anthony E Boitano; Caryn Ito; Peter W Zandstra
Journal:  Cell Stem Cell       Date:  2012-02-03       Impact factor: 24.633

Review 3.  Monocyte and macrophage heterogeneity.

Authors:  Siamon Gordon; Philip R Taylor
Journal:  Nat Rev Immunol       Date:  2005-12       Impact factor: 53.106

4.  Hematopoietic-cell transplantation at 50.

Authors:  Frederick R Appelbaum
Journal:  N Engl J Med       Date:  2007-10-11       Impact factor: 91.245

5.  Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution.

Authors:  Colleen Delaney; Shelly Heimfeld; Carolyn Brashem-Stein; Howard Voorhies; Ronald L Manger; Irwin D Bernstein
Journal:  Nat Med       Date:  2010-01-17       Impact factor: 53.440

6.  CD3(+) and/or CD14(+) depletion from cord blood mononuclear cells before ex vivo expansion culture improves total nucleated cell and CD34(+) cell yields.

Authors:  H Yang; S N Robinson; J Lu; W K Decker; D Xing; D Steiner; S Parmar; N Shah; R E Champlin; M Munsell; A Leen; C Bollard; P J Simmons; E J Shpall
Journal:  Bone Marrow Transplant       Date:  2009-10-19       Impact factor: 5.483

7.  Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

Authors:  Aya Ludin; Tomer Itkin; Shiri Gur-Cohen; Alexander Mildner; Elias Shezen; Karin Golan; Orit Kollet; Alexander Kalinkovich; Ziv Porat; Gabriele D'Uva; Amir Schajnovitz; Elena Voronov; David A Brenner; Ron N Apte; Steffen Jung; Tsvee Lapidot
Journal:  Nat Immunol       Date:  2012-09-16       Impact factor: 25.606

8.  Blood stem cell fate regulation by Delta-1-mediated rewiring of IL-6 paracrine signaling.

Authors:  Elizabeth Csaszar; Weijia Wang; Tatiana Usenko; Wenlian Qiao; Colleen Delaney; Irwin D Bernstein; Peter W Zandstra
Journal:  Blood       Date:  2013-11-15       Impact factor: 22.113

9.  Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.

Authors:  S Hazra; Y P R Jarajapu; V Stepps; S Caballero; J S Thinschmidt; L Sautina; N Bengtsson; S Licalzi; J Dominguez; T S Kern; M S Segal; J D Ash; D R Saban; S H Bartelmez; M B Grant
Journal:  Diabetologia       Date:  2012-11-29       Impact factor: 10.122
  9 in total

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