Literature DB >> 24482235

Regulation of induced pluripotent stem (iPS) cell induction by Wnt/β-catenin signaling.

Peilin Zhang1, Wen-Hsuan Chang, Brendan Fong, Fan Gao, Chunming Liu, Denise Al Alam, Saverio Bellusci, Wange Lu.   

Abstract

Wnt signaling has been implicated in promoting somatic cell reprogramming. However, its molecular mechanisms remain unknown. Here we report that Wnt/β-catenin enhances iPSCs induction at the early stage of reprogramming. The augmented reprogramming induced by β-catenin is not due to increased total cell population or activation of c-Myc. In addition, β-catenin interacts with reprogramming factors Klf4, Oct4, and Sox2, further enhancing expression of pluripotency circuitry genes. These studies reveal novel mechanisms underlying the regulation of reprogramming somatic cells to pluripotency by Wnt/β-catenin signaling.

Entities:  

Keywords:  Beta-catenin; Gene Expression; Induced Pluripotent Stem (iPS) Cell; Reprogramming; Wnt Signaling; c-myc

Mesh：

Substances：

Year:  2014        PMID： 24482235      PMCID： PMC3979361          DOI： 10.1074/jbc.M113.542845

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  34 in total

1.  LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism.

Authors:  Peter Cartwright; Cameron McLean; Allan Sheppard; Duane Rivett; Karen Jones; Stephen Dalton
Journal:  Development       Date:  2005-01-26       Impact factor: 6.868

2.  Functional interaction of beta-catenin with the transcription factor LEF-1.

Authors:  J Behrens; J P von Kries; M Kühl; L Bruhn; D Wedlich; R Grosschedl; W Birchmeier
Journal:  Nature       Date:  1996-08-15       Impact factor: 49.962

3.  XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos.

Authors:  M Molenaar; M van de Wetering; M Oosterwegel; J Peterson-Maduro; S Godsave; V Korinek; J Roose; O Destrée; H Clevers
Journal:  Cell       Date:  1996-08-09       Impact factor: 41.582

4.  Beta-catenin up-regulates Nanog expression through interaction with Oct-3/4 in embryonic stem cells.

Authors:  Yukinari Takao; Takashi Yokota; Hiroshi Koide
Journal:  Biochem Biophys Res Commun       Date:  2006-12-20       Impact factor: 3.575

5.  beta-catenin is a target for the ubiquitin-proteasome pathway.

Authors:  H Aberle; A Bauer; J Stappert; A Kispert; R Kemler
Journal:  EMBO J       Date:  1997-07-01       Impact factor: 11.598

6.  Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.

Authors:  Kazutoshi Takahashi; Shinya Yamanaka
Journal:  Cell       Date:  2006-08-10       Impact factor: 41.582

7.  Identification of c-MYC as a target of the APC pathway.

Authors:  T C He; A B Sparks; C Rago; H Hermeking; L Zawel; L T da Costa; P J Morin; B Vogelstein; K W Kinzler
Journal:  Science       Date:  1998-09-04       Impact factor: 47.728

8.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Authors:  Kazutoshi Takahashi; Koji Tanabe; Mari Ohnuki; Megumi Narita; Tomoko Ichisaka; Kiichiro Tomoda; Shinya Yamanaka
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

9.  Generation of germline-competent induced pluripotent stem cells.

Authors:  Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

10.  Wnt signalling regulates adult hippocampal neurogenesis.

Authors:  Dieter-Chichung Lie; Sophia A Colamarino; Hong-Jun Song; Laurent Désiré; Helena Mira; Antonella Consiglio; Edward S Lein; Sebastian Jessberger; Heather Lansford; Alejandro R Dearie; Fred H Gage
Journal:  Nature       Date:  2005-10-27       Impact factor: 49.962
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  25 in total

Review 1.  Regulatory factors of induced pluripotency: current status.

Authors:  Wei Zhao; Bo Ning; Chen Qian
Journal:  Stem Cell Investig       Date:  2014-07-22

2.  A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells.

Authors:  Jason Ross; Julia Busch; Ellen Mintz; Damian Ng; Alexandra Stanley; David Brafman; V Reid Sutton; Ignatia Van den Veyver; Karl Willert
Journal:  Cell Rep       Date:  2014-11-20       Impact factor: 9.423

3.  A novel culture system robustly maintained pluripotency of embryonic stem cells and accelerated somatic reprogramming by activating Wnt signaling.

Authors:  Shaojie Li; Xiao Lu; Haipeng He; Rong Cui; Xianxin Wang; Xiaoyun Wang; Xia Wu
Journal:  Am J Transl Res       Date:  2017-10-15       Impact factor: 4.060

4.  Expression and clinical significance of SALL4 and β-catenin in colorectal cancer.

Authors:  Liliang Hao; Yan Zhao; Zhen Wang; Hongzhuan Yin; Xin Zhang; Tao He; Shanshan Song; Shaolong Sun; Baosheng Wang; Zhijie Li; Qi Su
Journal:  J Mol Histol       Date:  2016-01-16       Impact factor: 2.611

5.  E-Cadherin repression increases amount of cancer stem cells in human A549 lung adenocarcinoma and stimulates tumor growth.

Authors:  M Farmakovskaya; N Khromova; V Rybko; V Dugina; B Kopnin; P Kopnin
Journal:  Cell Cycle       Date:  2016       Impact factor: 4.534

Review 6.  Oncogenesis and induced pluripotency - commonalities of signalling pathways.

Authors:  Marta Klimczak
Journal:  Contemp Oncol (Pozn)       Date:  2015

Review 7.  Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling.

Authors:  Wen-Hui Lien; Elaine Fuchs
Journal:  Genes Dev       Date:  2014-07-15       Impact factor: 11.361

Review 8.  G protein-coupled receptors in stem cell maintenance and somatic reprogramming to pluripotent or cancer stem cells.

Authors:  Hye Yeon Choi; Subbroto Kumar Saha; Kyeongseok Kim; Sangsu Kim; Gwang-Mo Yang; BongWoo Kim; Jin-hoi Kim; Ssang-Goo Cho
Journal:  BMB Rep       Date:  2015-02       Impact factor: 4.778

9.  Signalling Through Retinoic Acid Receptors is Required for Reprogramming of Both Mouse Embryonic Fibroblast Cells and Epiblast Stem Cells to Induced Pluripotent Stem Cells.

Authors:  Jian Yang; Wei Wang; Jolene Ooi; Lia S Campos; Liming Lu; Pentao Liu
Journal:  Stem Cells       Date:  2015-05       Impact factor: 6.277

10.  Wnt/β-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development.

Authors:  Yujin Zhang; Lung-Kun Yeh; Suohui Zhang; Mindy Call; Yong Yuan; Mayu Yasunaga; Winston W-Y Kao; Chia-Yang Liu
Journal:  Development       Date:  2015-10-01       Impact factor: 6.868
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