Literature DB >> 24482049

A light-activated metal complex targets both DNA and RNA in a fluorescent in vitro transcription and translation assay.

David K Heidary1, Edith C Glazer.   

Abstract

A coupled in vitro transcription and translation (IVTT) assay that uses GFP as a fluorescent reporter allowed the potency of a light-activated cytotoxic ruthenium agent to be quantified. The compound inhibits the function of both DNA and mRNA only upon light activation. The IVTT functional assay provides estimates of potency that are consistent with cellular cytotoxicity values, in marked contrast to the values obtained from traditional DNA-damage assays.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cancer; cisplatin; drug discovery; high-throughput screening; ruthenium

Mesh：

Substances：

Year:  2014        PMID： 24482049     DOI： 10.1002/cbic.201300681

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  10 in total

1.  An Overview Of Photosubstitution Reactions Of Ru(II) Imine Complexes And Their Application In Photobiology And Photodynamic Therapy.

Authors:  Jessica K White; Russell H Schmehl; Claudia Turro
Journal:  Inorganica Chim Acta       Date:  2016-06-18       Impact factor: 2.545

2.  Photochemical Properties and Structure-Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents.

Authors:  Dmytro Havrylyuk; David K Heidary; Leona Nease; Sean Parkin; Edith C Glazer
Journal:  Eur J Inorg Chem       Date:  2017-02-15       Impact factor: 2.524

3.  Strained, Photoejecting Ru(II) Complexes that are Cytotoxic Under Hypoxic Conditions.

Authors:  John Roque; Dmytro Havrylyuk; Patrick C Barrett; Tariq Sainuddin; Julia McCain; Katsuya Colón; William T Sparks; Evan Bradner; Susan Monro; David Heidary; Colin G Cameron; Edith C Glazer; Sherri A McFarland
Journal:  Photochem Photobiol       Date:  2019-12-06       Impact factor: 3.421

4.  Photochemical and Photobiological Activity of Ru(II) Homoleptic and Heteroleptic Complexes Containing Methylated Bipyridyl-type Ligands.

Authors:  Lars Kohler; Leona Nease; Pascal Vo; Jenna Garofolo; David K Heidary; Randolph P Thummel; Edith C Glazer
Journal:  Inorg Chem       Date:  2017-09-26       Impact factor: 5.165

5.  Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer.

Authors:  M Dickerson; B Howerton; Y Bae; E Glazer
Journal:  J Mater Chem B       Date:  2015-12-01       Impact factor: 6.331

6.  Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.

Authors:  John A Roque Iii; Houston D Cole; Patrick C Barrett; Liubov M Lifshits; Rachel O Hodges; Susy Kim; Gagan Deep; Antonio Francés-Monerris; Marta E Alberto; Colin G Cameron; Sherri A McFarland
Journal:  J Am Chem Soc       Date:  2022-04-28       Impact factor: 16.383

7.  A High-Throughput Screening Assay Using a Photoconvertable Protein for Identifying Inhibitors of Transcription, Translation, or Proteasomal Degradation.

Authors:  David K Heidary; Ashley Fox; Chris I Richards; Edith C Glazer
Journal:  SLAS Discov       Date:  2017-01-06       Impact factor: 3.341

8.  Ultrafast in cellulo photoinduced dynamics processes of the paradigm molecular light switch [Ru(bpy)2dppz](2.).

Authors:  Alejandro De la Cadena; Dar'ya Davydova; Tatiana Tolstik; Christian Reichardt; Sapna Shukla; Denis Akimov; Rainer Heintzmann; Jürgen Popp; Benjamin Dietzek
Journal:  Sci Rep       Date:  2016-09-20       Impact factor: 4.379

Review 9.  Biological activities of polypyridyl-type ligands: implications for bioinorganic chemistry and light-activated metal complexes.

Authors:  Austin C Hachey; Dmytro Havrylyuk; Edith C Glazer
Journal:  Curr Opin Chem Biol       Date:  2021-03-30       Impact factor: 8.822

10.  Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes.

Authors:  Yang Sun; David K Heidary; Zhihui Zhang; Christopher I Richards; Edith C Glazer
Journal:  Mol Pharm       Date:  2018-06-30       Impact factor: 4.939
  10 in total

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