Literature DB >> 2448163

Influence of probe structure on unique (regiospecific) cleavage of RNA by RNase H.

V G Metelev1, G V Zayakina, I L Ryabushenko, N F Krynetskaya, E A Romanova, T S Oretskaya, Z A Shabarova.   

Abstract

Chimeric oligo(ribo-deoxyribo)nucleotides with an internucleotide pyrophosphate bond are novel probes for regiospecific hydrolysis of RNA by RNase H. It has been shown that the use of d(TGTGTAT)ppGCCAU leads to unique hydrolysis of the TMV RNA fragment pAAUGGCAUACAC between C10 and A11.

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Year:  1988        PMID： 2448163     DOI： 10.1016/0014-5793(88)81429-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  2 in total

1.  How does RNase H recognize a DNA.RNA hybrid?

Authors:  H Nakamura; Y Oda; S Iwai; H Inoue; E Ohtsuka; S Kanaya; S Kimura; C Katsuda; K Katayanagi; K Morikawa
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

2.  RNase H is responsible for the non-specific inhibition of in vitro translation by 2'-O-alkyl chimeric oligonucleotides: high affinity or selectivity, a dilemma to design antisense oligomers.

Authors:  B Larrouy; C Boiziau; B Sproat; J J Toulmé
Journal:  Nucleic Acids Res       Date:  1995-09-11       Impact factor: 16.971
  2 in total

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