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Literature DB >> 2448141

Haemoglobin A2 in newborn infants of different maturity.

Abstract

From 70 infants born after gestation periods of 28-41 weeks HbF and HbA2 were determined in the cord blood; HbA was calculated from the two values. HbF decreased with maturity, HbA and HbA2 increased. The percentage of HbA2 calculated from the sum of HbA + HbA2 (non-fetal Hb) increased from 0.57% to 0.83% with maturity. These values are much lower than those in adult controls (1.83%). The results show that during development the synthesis of the delta-globin chains lags behind that of the beta-globin chains. This is remarkable considering the location of the delta-globin gene within the beta-globin like gene cluster.

Entities: Gene Species

Mesh：

Substances：

Year: 1987 PMID： 2448141 DOI： 10.1007/bf02467363

Source DB: PubMed Journal: Eur J Pediatr ISSN： 0340-6199 Impact factor: 3.183

13 in total

9. The haemoglobin of the human foetus and infant. Electrophoretic and spectroscopic differentiation of adult and foetal types.

Authors: G H BEAVEN; H HOCH; E R HOLIDAY
Journal: Biochem J Date: 1951-08 Impact factor: 3.857

10. The primate psi beta 1 gene. An ancient beta-globin pseudogene.

Authors: S Harris; P A Barrie; M L Weiss; A J Jeffreys
Journal: J Mol Biol Date: 1984-12-25 Impact factor: 5.469

1 in total

1. Switch of delta and beta chains in fetus.

Authors: S Ozsoylu
Journal: Eur J Pediatr Date: 1988-08 Impact factor: 3.183

1 in total

Haemoglobin A2 in newborn infants of different maturity.

1. Haemoglobin and red cells in the human foetus; III. Foetal and adult haemoglobin.

2. [Hematology of early life].

3. New hemoglobin in normal adult blood.

4. Chromosomal localization of human beta globin gene on human chromosome 11 in somatic cell hybrids.

5. Microchromatography of hemoglobins. II. A rapid method for the determination of hemoglobin A2.

6. Molecular cloning and characterization of the human beta-like globin gene cluster.

Review 7. Haemoglobin synthesis during human fetal development.

8. Isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee.

9. The haemoglobin of the human foetus and infant. Electrophoretic and spectroscopic differentiation of adult and foetal types.

10. The primate psi beta 1 gene. An ancient beta-globin pseudogene.

1. Switch of delta and beta chains in fetus.