BACKGROUND: Data comparing pregnancy outcome in hyperthyroid women with euthyroid women are scarce. Hence, this study was carried out to assess the maternal and fetal outcome in pregnant women with hyperthyroidism to ascertain the effect of disease on pregnancy. METHODOLOGY: This retrospective study was conducted over a period of 28 years. We compared the maternal and fetal outcomes of 208 hyperthyroid women with 403 healthy controls, between women with well-controlled and uncontrolled disease and amongst women diagnosed with hyperthyroidism before and during pregnancy. RESULTS: Maternal outcome: women with hyperthyroidism were at increased risk for preeclampsia (OR = 3.94), intrauterine growth restriction (OR = 2.16), spontaneous preterm labor (OR = 1.73), preterm birth (OR = 1.7), gestational diabetes mellitus (OR = 1.8), and cesarean delivery (OR = 1.47). Hyperthyroid women required induction of labor more frequently (OR = 3.61). Fetal outcome: newborns of hyperthyroid mothers had lower birth weight than normal ones (p = 0.0001). Women with uncontrolled disease had higher odds for still birth (OR = 8.42; 95% CI: 2.01-35.2) and lower birth weight (p = 0.0001). CONCLUSIONS: Obstetrical complications were higher in women with hyperthyroidism than normal women. Outcome was worsened by uncontrolled disease. Women with pregestational hyperthyroidism had better outcomes than those diagnosed with it during pregnancy.
BACKGROUND: Data comparing pregnancy outcome in hyperthyroid women with euthyroid women are scarce. Hence, this study was carried out to assess the maternal and fetal outcome in pregnant women with hyperthyroidism to ascertain the effect of disease on pregnancy. METHODOLOGY: This retrospective study was conducted over a period of 28 years. We compared the maternal and fetal outcomes of 208 hyperthyroid women with 403 healthy controls, between women with well-controlled and uncontrolled disease and amongst women diagnosed with hyperthyroidism before and during pregnancy. RESULTS: Maternal outcome: women with hyperthyroidism were at increased risk for preeclampsia (OR = 3.94), intrauterine growth restriction (OR = 2.16), spontaneous preterm labor (OR = 1.73), preterm birth (OR = 1.7), gestational diabetes mellitus (OR = 1.8), and cesarean delivery (OR = 1.47). Hyperthyroid women required induction of labor more frequently (OR = 3.61). Fetal outcome: newborns of hyperthyroid mothers had lower birth weight than normal ones (p = 0.0001). Women with uncontrolled disease had higher odds for still birth (OR = 8.42; 95% CI: 2.01-35.2) and lower birth weight (p = 0.0001). CONCLUSIONS: Obstetrical complications were higher in women with hyperthyroidism than normal women. Outcome was worsened by uncontrolled disease. Women with pregestational hyperthyroidism had better outcomes than those diagnosed with it during pregnancy.
Authors: Arash Derakhshan; Robin P Peeters; Peter N Taylor; Sofie Bliddal; David M Carty; Margreet Meems; Bijay Vaidya; Liangmiao Chen; Bridget A Knight; Farkhanda Ghafoor; Polina V Popova; Lorena Mosso; Emily Oken; Eila Suvanto; Aya Hisada; Jun Yoshinaga; Suzanne J Brown; Judit Bassols; Juha Auvinen; Wichor M Bramer; Abel López-Bermejo; Colin M Dayan; Robert French; Laura Boucai; Marina Vafeiadi; Elena N Grineva; Victor J M Pop; Tanja G Vrijkotte; Leda Chatzi; Jordi Sunyer; Ana Jiménez-Zabala; Isolina Riaño; Marisa Rebagliato; Xuemian Lu; Amna Pirzada; Tuija Männistö; Christian Delles; Ulla Feldt-Rasmussen; Erik K Alexander; Scott M Nelson; Layal Chaker; Elizabeth N Pearce; Mònica Guxens; Eric A P Steegers; John P Walsh; Tim I M Korevaar Journal: Lancet Diabetes Endocrinol Date: 2020-06 Impact factor: 44.867
Authors: Lauren E Johns; Kelly K Ferguson; Thomas F McElrath; Bhramar Mukherjee; John D Meeker Journal: Environ Health Perspect Date: 2016-05-06 Impact factor: 9.031
Authors: Lauren E Johns; Kelly K Ferguson; Thomas F McElrath; Bhramar Mukherjee; Ellen W Seely; John D Meeker Journal: PLoS One Date: 2017-01-06 Impact factor: 3.240