Literature DB >> 24481020

Myxoedema coma: an almost forgotten, yet still existing cause of multiorgan failure.

Louise Havkrog Salomo1, Adam Hoegsbro Laursen, Nanna Reiter, Ulla Feldt-Rasmussen.   

Abstract

A 48-year-old man was admitted to department of emergency medicine at a tertiary referral hospital due to dizziness and fatigue. Clinical features on admission were non-pitting oedema, dry skin, very sparse hair, a hoarse voice, hypothermia (rectal temperature 28.7°C), macroglossia, sinus bradycardia and slow cerebration. Blood tests revealed severe hypothyroidism. During admission, the patient developed respiratory failure, renal failure, bleeding symptoms and diffuse colitis. The patient was treated with hydrocortisone and levothyroxine and he survived miraculously. This case describes a patient with myxoedema coma with severe hypothermia and cardiac involvement with development of multiorgan dysfunction all linked to the severe depletion of triiodothyronine.

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Year:  2014        PMID: 24481020      PMCID: PMC3912383          DOI: 10.1136/bcr-2013-203223

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  7 in total

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Journal:  Med Clin North Am       Date:  2012-02-14       Impact factor: 5.456

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Journal:  Med Klin (Munich)       Date:  1997-09-15

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Journal:  J Clin Endocrinol Metab       Date:  1975-02       Impact factor: 5.958

4.  Effect of acute desmopressin and of long-term thyroxine replacement on haemostasis in hypothyroidism.

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Journal:  Clin Endocrinol (Oxf)       Date:  1995-04       Impact factor: 3.478

5.  Cardiac enzyme changes in myxedema coma.

Authors:  P E Hickman; W Silvester; A A Musk; G H McLellan; A Harris
Journal:  Clin Chem       Date:  1987-04       Impact factor: 8.327

6.  Treatment of myxoedema coma--factors associated with fatal outcome.

Authors:  B Hylander; U Rosenqvist
Journal:  Acta Endocrinol (Copenh)       Date:  1985-01

7.  Myxedema coma: a new look into an old crisis.

Authors:  Vivek Mathew; Raiz Ahmad Misgar; Sujoy Ghosh; Pradip Mukhopadhyay; Pradip Roychowdhury; Kaushik Pandit; Satinath Mukhopadhyay; Subhankar Chowdhury
Journal:  J Thyroid Res       Date:  2011-09-15
  7 in total
  11 in total

1.  Myxedema Coma with Reversible Cardiopulmonary Failure: a Rare Entity in 21St Century.

Authors:  Prajwal Dhakal; Manisha Pant; Pranab Sharma Acharya; Sumit Dahal; Vijaya Raj Bhatt
Journal:  Maedica (Buchar)       Date:  2015-09

2.  Myxoedema coma in the setting of hyperglycaemic hyperosmolar state.

Authors:  Alexander Spyridoulias; Muhammad Shakeel Riaz
Journal:  BMJ Case Rep       Date:  2016-01-11

Review 3.  Central hypothyroidism and its role for cardiovascular risk factors in hypopituitary patients.

Authors:  Ulla Feldt-Rasmussen; Marianne Klose
Journal:  Endocrine       Date:  2016-08-01       Impact factor: 3.633

4.  Are dizziness-related symptoms signals for suboptimal treatment of hypothyroidism? New insights from the FDA adverse event reporting system (FAERS) database.

Authors:  Carla Carnovale; Vera Battini; Faizan Mazhar; Giulia Mosini; Michele Gringeri; Andrea Vicenzi; Emilio Clementi; Sonia Radice
Journal:  Eur J Clin Pharmacol       Date:  2020-01-23       Impact factor: 2.953

5.  Thoracentesis-reverting cardiac tamponade physiology in a patient with myxedema coma and large pleural effusion.

Authors:  Monia E Werlang; Mario R Pimentel; Jose L Diaz-Gomez
Journal:  Proc (Bayl Univ Med Cent)       Date:  2017-07

Review 6.  Medical and Nonstroke Neurologic Causes of Acute, Continuous Vestibular Symptoms.

Authors:  Jonathan A Edlow; David E Newman-Toker
Journal:  Neurol Clin       Date:  2015-08       Impact factor: 3.787

7.  Myasthenic Crisis Complicated with Myxedema, Positive for Both Anti-acetylcholine Receptor and Anti-muscle-specific Tyrosine Kinase Antibodies.

Authors:  Kazuhiro Horiuchi; Azusa Nagai; Masahiro Wakita; Shotaro Ito; Kei Takamura; Hideki Houzen
Journal:  Intern Med       Date:  2017-11-01       Impact factor: 1.271

8.  Myxedema coma: A case report of pediatric emergency care.

Authors:  Yueniu Zhu; Wenjuan Qiu; Mengyan Deng; Xiaodong Zhu
Journal:  Medicine (Baltimore)       Date:  2017-05       Impact factor: 1.889

9.  Intracerebral Bleeding and Massive Pericardial Effusion as Presenting Symptoms of Myxedema Crisis.

Authors:  M Kirsch; C Rimpau; C H Nickel; P Baier
Journal:  Case Rep Emerg Med       Date:  2017-02-01

10.  Split high-dose oral levothyroxine treatment as a successful therapy option in myxedema coma.

Authors:  Suranut Charoensri; Chutintorn Sriphrapradang; Hataikarn Nimitphong
Journal:  Clin Case Rep       Date:  2017-09-08
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