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Literature DB >> 24480852

Unraveling intestinal stem cell behavior with models of crypt dynamics.

Alexis J Carulli¹, Linda C Samuelson, Santiago Schnell.

Abstract

The definition, regulation and function of intestinal stem cells (ISCs) has been hotly debated. Recent discoveries have started to clarify the nature of ISCs, but many questions remain. This review discusses the current advances and controversies of ISC biology as well as theoretical compartmental models that have been coupled with in vivo experimentation to investigate the mechanisms of ISC dynamics during homeostasis, tumorigenesis, repair and development. We conclude our review by discussing the key lingering questions in the field and proposing how many of these questions can be addressed using both compartmental models and experimental techniques.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers

Year: 2014 PMID： 24480852 PMCID： PMC4007491 DOI： 10.1039/c3ib40163d

Source DB: PubMed Journal: Integr Biol (Camb) ISSN： 1757-9694 Impact factor: 2.192

100 in total

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Authors: Laurianne Van Landeghem; M Agostina Santoro; Adrienne E Krebs; Amanda T Mah; Jeffrey J Dehmer; Adam D Gracz; Brooks P Scull; Kirk McNaughton; Scott T Magness; P Kay Lund
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2012-02-23 Impact factor: 4.052

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Journal: J Biol Chem Date: 1999-03-05 Impact factor: 5.157

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Journal: Philos Trans R Soc Lond B Biol Sci Date: 1998-06-29 Impact factor: 6.237

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Journal: J Biol Chem Date: 1997-09-19 Impact factor: 5.157

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Journal: Am J Physiol Date: 1996-07

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Authors: Michael E Rothenberg; Ysbrand Nusse; Tomer Kalisky; John J Lee; Piero Dalerba; Ferenc Scheeren; Neethan Lobo; Subhash Kulkarni; Sopheak Sim; Dalong Qian; Philip A Beachy; Pankaj J Pasricha; Stephen R Quake; Michael F Clarke
Journal: Gastroenterology Date: 2012-02-11 Impact factor: 22.682

7. Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.

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Journal: Proc Natl Acad Sci U S A Date: 1995-11-21 Impact factor: 11.205

8. Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).

Authors: Aurélie Durand; Bridgitte Donahue; Grégory Peignon; Franck Letourneur; Nicolas Cagnard; Christian Slomianny; Christine Perret; Noah F Shroyer; Béatrice Romagnolo
Journal: Proc Natl Acad Sci U S A Date: 2012-05-14 Impact factor: 11.205

9. Modelling the spatio-temporal cell dynamics reveals novel insights on cell differentiation and proliferation in the small intestinal crypt.

Authors: Carmen Pin; Alastair J M Watson; Simon R Carding
Journal: PLoS One Date: 2012-05-18 Impact factor: 3.240

10. Computational modelling of cell chain migration reveals mechanisms that sustain follow-the-leader behaviour.

Authors: Michelle L Wynn; Paul M Kulesa; Santiago Schnell
Journal: J R Soc Interface Date: 2012-01-04 Impact factor: 4.118

26 in total

Review 1. Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology.

Authors: Thomas E Wallach; James R Bayrer
Journal: J Pediatr Gastroenterol Nutr Date: 2017-02 Impact factor: 2.839

2. Asymmetric cell division-dominant neutral drift model for normal intestinal stem cell homeostasis.

Authors: Yoshitatsu Sei; Jianying Feng; Carson C Chow; Stephen A Wank
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2018-10-25 Impact factor: 4.052

3. Unraveling the Control of Cell Cycle Periods during Intestinal Stem Cell Differentiation.

Authors: Richard Ballweg; Suengwon Lee; Xiaonan Han; Philip K Maini; Helen Byrne; Christian I Hong; Tongli Zhang
Journal: Biophys J Date: 2018-11-03 Impact factor: 4.033

4. Determining the control networks regulating stem cell lineages in colonic crypts.

Authors: Jienian Yang; David E Axelrod; Natalia L Komarova
Journal: J Theor Biol Date: 2017-06-29 Impact factor: 2.691

Review 5. Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal.

Authors: Kyoko Ito; Keisuke Ito
Journal: Annu Rev Cell Dev Biol Date: 2016-08-01 Impact factor: 13.827

6. Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture.

Authors: Toru Matsu-Ura; Andrey Dovzhenok; Eitaro Aihara; Jill Rood; Hung Le; Yan Ren; Andrew E Rosselot; Tongli Zhang; Choogon Lee; Karl Obrietan; Marshall H Montrose; Sookkyung Lim; Sean R Moore; Christian I Hong
Journal: Mol Cell Date: 2016-11-17 Impact factor: 17.970

7. Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy.

Authors: Barun Das; Kevin Okamoto; John Rabalais; Philip A Kozan; Ronald R Marchelletta; Matthew D McGeough; Nassim Durali; Maria Go; Kim E Barrett; Soumita Das; Mamata Sivagnanam
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2019-08-21 Impact factor: 4.052