Eudes Euler de Souza Lucena1, Fausto Pierdoná Guzen2, José Rodolfo Lopes de Paiva Cavalcanti3, Carlos Augusto Galvão Barboza4, Expedito Silva do Nascimento Júnior5, Jeferson de Sousa Cavalcante6. 1. Assistant Professor, Laboratory of Experimental Neurology, Health Science Center, State University of Rio Grande do Norte, Mossoró, RN, Brazil. Electronic address: eudeseuler@hotmail.com. 2. Adjunct Professor, Laboratory of Experimental Neurology, Health Science Center, State University of Rio Grande do Norte, Mossoró, RN, Brazil. 3. Assistant Professor, Laboratory of Experimental Neurology, Health Science Center, State University of Rio Grande do Norte, Mossoró, RN, Brazil. 4. Associate Professor, Department of Morphology, Bioscience Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil. 5. Adjunct Professor, Laboratory of Neuroanatomy, Department of Morphology, Bioscience Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil. 6. Associate Professor, Laboratory of Neuroanatomy, Department of Morphology, Bioscience Center, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Abstract
PURPOSE: Peripheral nerve trauma results in functional loss in the innervated organ, and recovery without surgical intervention is rare. Many surgical techniques can be used for repair in experimental models. The authors investigated the source and delivery method of stem cells in experimental outcomes, seeking to clarify whether stem cells must be differentiated in the injured facial nerve and improve the regenerative process. MATERIALS AND METHODS: The following key terms were used: nervous regeneration, nerve regeneration, facial nerve regeneration, stem cells, embryonic stem cells, fetal stem cells, adult stem cells, facial nerve, facial nerve trauma, and facial nerve traumatism. The search was restricted to experimental studies that applied stem cell therapy and tissue engineering for nerve repair. RESULTS: Eight studies meeting the inclusion criteria were reviewed. Different sources of stem and precursor cells were explored (bone marrow mesenchymal stem cells, adipose-derived stem cells, dental pulp cells, and neural stem cells) for their potential application in the scenario of facial nerve injuries. Different material conduits (vases, collagen, and polyglycolic acid) were used as bridges. Immunochemistry and electrophysiology are the principal methods for analyzing regenerative effects. Although recent studies have shown that stem cells can act as a promising bridge for nerve repair, considerable optimization of these therapies will be required for their potential to be realized in a clinical setting. CONCLUSION: Based on these studies, the use of stem cells derived from different sources presents promising results related to facial nerve regeneration and produces effective functional results. The use of tubes also optimizes nerve repair, thus promoting greater myelination and axonal growth of peripheral nerves.
PURPOSE: Peripheral nerve trauma results in functional loss in the innervated organ, and recovery without surgical intervention is rare. Many surgical techniques can be used for repair in experimental models. The authors investigated the source and delivery method of stem cells in experimental outcomes, seeking to clarify whether stem cells must be differentiated in the injured facial nerve and improve the regenerative process. MATERIALS AND METHODS: The following key terms were used: nervous regeneration, nerve regeneration, facial nerve regeneration, stem cells, embryonic stem cells, fetal stem cells, adult stem cells, facial nerve, facial nerve trauma, and facial nerve traumatism. The search was restricted to experimental studies that applied stem cell therapy and tissue engineering for nerve repair. RESULTS: Eight studies meeting the inclusion criteria were reviewed. Different sources of stem and precursor cells were explored (bone marrow mesenchymal stem cells, adipose-derived stem cells, dental pulp cells, and neural stem cells) for their potential application in the scenario of facial nerve injuries. Different material conduits (vases, collagen, and polyglycolic acid) were used as bridges. Immunochemistry and electrophysiology are the principal methods for analyzing regenerative effects. Although recent studies have shown that stem cells can act as a promising bridge for nerve repair, considerable optimization of these therapies will be required for their potential to be realized in a clinical setting. CONCLUSION: Based on these studies, the use of stem cells derived from different sources presents promising results related to facial nerve regeneration and produces effective functional results. The use of tubes also optimizes nerve repair, thus promoting greater myelination and axonal growth of peripheral nerves.
Authors: Qunzhou Zhang; Phuong D Nguyen; Shihong Shi; Justin C Burrell; Qilin Xu; Kacy D Cullen; Anh D Le Journal: Mol Neurobiol Date: 2018-01-25 Impact factor: 5.590
Authors: Fuat Baris Bengur; Conrad Stoy; Mary A Binko; Wayne Vincent Nerone; Caroline Nadia Fedor; Mario G Solari; Kacey G Marra Journal: Tissue Eng Part B Rev Date: 2021-04-13 Impact factor: 7.376
Authors: Eudes Euler de Souza Lucena; Fausto Pierdoná Guzen; José Rodolfo Lopes de Paiva Cavalcanti; Maria Jocileide de Medeiros Marinho; Wogelsanger Oliveira Pereira; Carlos Augusto Galvão Barboza; Miriam Stela Mariz de Oliveira Costa; Expedito Silva do Nascimento Júnior; Jeferson Sousa Cavalcante Journal: ScientificWorldJournal Date: 2014-12-29
Authors: Robert Gaudin; Christian Knipfer; Anders Henningsen; Ralf Smeets; Max Heiland; Tessa Hadlock Journal: Biomed Res Int Date: 2016-07-31 Impact factor: 3.411